HCSGD entry for CRYZ
1. General information
| Official gene symbol | CRYZ |
|---|---|
| Entrez ID | 1429 |
| Gene full name | crystallin, zeta (quinone reductase) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003730 | MRNA 3'-UTR binding | IDA | molecular_function |
| GO:0003960 | NADPH:quinone reductase activity | IDA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0007601 | Visual perception | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0042178 | Xenobiotic catabolic process | IDA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0051289 | Protein homotetramerization | IPI | biological_process |
| GO:0070402 | NADPH binding | IDA | molecular_function |
| GO:0070404 | NADH binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8806617340 | 0.0474877246 | 0.9999902473 | 0.4085749346 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0435952855 |
| GSE13712_SHEAR | Up | 0.0909447029 |
| GSE13712_STATIC | Down | -0.1532179724 |
| GSE19018 | Up | 0.4167081405 |
| GSE19899_A1 | Down | -0.0441870531 |
| GSE19899_A2 | Down | -0.1235057133 |
| PubMed_21979375_A1 | Down | -0.3455595514 |
| PubMed_21979375_A2 | Up | 0.0183871231 |
| GSE35957 | Down | -0.9291493560 |
| GSE36640 | Up | 0.0547746282 |
| GSE54402 | Down | -0.0487459121 |
| GSE9593 | Down | -0.1048766735 |
| GSE43922 | Down | -0.1477056789 |
| GSE24585 | Down | -0.1930552730 |
| GSE37065 | Up | 0.2287218028 |
| GSE28863_A1 | Down | -0.3587414454 |
| GSE28863_A2 | Up | 0.0168314011 |
| GSE28863_A3 | Down | -0.3534888004 |
| GSE28863_A4 | Down | -0.1335100204 |
| GSE48662 | Down | -0.6912992435 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 2'-Monophosphoadenosine 5'-Diphosphoribose | DB03461 | EXPT02293 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030176 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036137 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26078718 | In this study, we report that expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a cytoplasmic 2-electron reductase, is induced during oncogene-induced senescence (OIS) |
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