HCSGD entry for MIB2
1. General information
| Official gene symbol | MIB2 |
|---|---|
| Entrez ID | 142678 |
| Gene full name | mindbomb E3 ubiquitin protein ligase 2 |
| Other gene symbols | ZZANK1 ZZZ5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | IEA | cellular_component |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IEA | molecular_function |
| GO:0004871 | Signal transducer activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005769 | Early endosome | IEA | cellular_component |
| GO:0007219 | Notch signaling pathway | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1836641389 | 0.9410149424 | 0.8378204159 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0698458421 |
| GSE13712_SHEAR | Down | -0.0659476909 |
| GSE13712_STATIC | Down | -0.1369473379 |
| GSE19018 | Up | 0.1161705300 |
| GSE19899_A1 | Up | 0.0439676111 |
| GSE19899_A2 | Up | 0.3512776891 |
| PubMed_21979375_A1 | Up | 0.3253336034 |
| PubMed_21979375_A2 | Up | 0.4543789345 |
| GSE35957 | Down | -0.1006401804 |
| GSE36640 | Up | 0.2539349469 |
| GSE54402 | Up | 0.1351708590 |
| GSE9593 | Up | 0.2342042790 |
| GSE43922 | Up | 0.0602479075 |
| GSE24585 | Up | 0.2959425684 |
| GSE37065 | Down | -0.3585094084 |
| GSE28863_A1 | Down | -0.1328650103 |
| GSE28863_A2 | Up | 0.1859697637 |
| GSE28863_A3 | Up | 0.2241475595 |
| GSE28863_A4 | Down | -0.0775192672 |
| GSE48662 | Up | 0.5540333927 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018014 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042577 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
