HCSGD entry for PARP1
1. General information
| Official gene symbol | PARP1 |
|---|---|
| Entrez ID | 142 |
| Gene full name | poly (ADP-ribose) polymerase 1 |
| Other gene symbols | ADPRT ADPRT 1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0000723 | Telomere maintenance | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | IDA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005635 | Nuclear envelope | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005667 | Transcription factor complex | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006284 | Base-excision repair | IEA | biological_process |
| GO:0006302 | Double-strand break repair | IMP | biological_process |
| GO:0006351 | Transcription, DNA-templated | TAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006471 | Protein ADP-ribosylation | IDA | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016540 | Protein autoprocessing | IEA | biological_process |
| GO:0019899 | Enzyme binding | IEA | molecular_function |
| GO:0023019 | Signal transduction involved in regulation of gene expression | IEA | biological_process |
| GO:0030225 | Macrophage differentiation | TAS | biological_process |
| GO:0032869 | Cellular response to insulin stimulus | IDA | biological_process |
| GO:0040009 | Regulation of growth rate | IEA | biological_process |
| GO:0042769 | DNA damage response, detection of DNA damage | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0047485 | Protein N-terminus binding | IPI | molecular_function |
| GO:0051287 | NAD binding | IEA | molecular_function |
| GO:0060391 | Positive regulation of SMAD protein import into nucleus | IEA | biological_process |
| GO:0070212 | Protein poly-ADP-ribosylation | IDA | biological_process |
| GO:0070412 | R-SMAD binding | IEA | molecular_function |
| GO:2000679 | Positive regulation of transcription regulatory region DNA binding | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9987936135 | 0.0022135861 | 0.9999902473 | 0.0907090062 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4157944674 |
| GSE13712_SHEAR | Down | -0.4935181788 |
| GSE13712_STATIC | Down | -0.2360944293 |
| GSE19018 | Down | -0.0368187377 |
| GSE19899_A1 | Down | -0.8279377859 |
| GSE19899_A2 | Down | -0.6314778298 |
| PubMed_21979375_A1 | Down | -0.6192878207 |
| PubMed_21979375_A2 | Down | -0.5827022210 |
| GSE35957 | Down | -1.1656855481 |
| GSE36640 | Down | -1.7253276849 |
| GSE54402 | Down | -0.3442616213 |
| GSE9593 | Down | -0.6912703137 |
| GSE43922 | Down | -0.5633115755 |
| GSE24585 | Down | -0.0802257657 |
| GSE37065 | Down | -0.4144778793 |
| GSE28863_A1 | Down | -0.2912616273 |
| GSE28863_A2 | Down | -0.1055446073 |
| GSE28863_A3 | Up | 0.1117150938 |
| GSE28863_A4 | Down | -0.0361313590 |
| GSE48662 | Down | -0.2898978907 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Entries Per Page
Displaying Page of
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Carba-Nicotinamide-Adenine-Dinucleotide | DB02498 | EXPT00963 |
| NU1025 | DB02690 | EXPT02396 |
| Nicotinamide | DB02701 | EXPT02307 |
| 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone | DB03072 | EXPT01494 |
| 3-Methoxybenzamide | DB03073 | EXPT00177 |
| 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide | DB03509 | EXPT00973 |
| 3,4-Dihydro-5-Methyl-Isoquinolinone | DB03722 | EXPT01196 |
| 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide | DB04010 | EXPT00788 |
| 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE | DB07096 | - |
| Veliparib | DB07232 | - |
| trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium | DB07330 | - |
| 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE | DB07787 | - |
| Olaparib | DB09074 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019791 | qRT-PCR;Microarray | Functional MTI (Weak) | 20584986 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030724 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036020 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1225-3p | MIMAT0005573 | MIRT036540 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-874-3p | MIMAT0004911 | MIRT037766 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038771 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039741 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041220 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041920 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042808 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045417 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT045879 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046091 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT046137 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-223-3p | MIMAT0000280 | MIRT052650 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 23757351 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25582120 | Mechanistically, telomere fusions require either the classical non-homologous end-joining (C-NHEJ) pathway dependent on Ku70/80 and LIG4, or the alternative non-homologous end-joining (A-NHEJ), which relies on PARP1 and LIG3 |
| 25049175 | The highly conserved abundant nuclear protein poly(ADP-ribose)polymerase1 (PARP1) functions at the center of cellular stress response and is mainly implied in DNA damage repair mechanism |
| 25049175 | Since brain is the principal organ vulnerable to oxidative stress and inflammatory responses, upon stress encounters robust DNA damage can occur and intense PARP1 activation may result that will lead to various CNS diseases |
| 25049175 | In the context of soaring interest towards PARP1 as a therapeutic target for newer pharmacological interventions, here in the present review, we are attempting to give a silhouette of the role of PARP1 in the neurological diseases and the potential of its inhibitors to enter clinical translation, along with its structural and functional aspects |
| 25049175 | In the context of soaring interest towards PARP1 as a therapeutic target for newer pharmacological interventions, here in the present review, we are attempting to give a silhouette of the role of PARP1 in the neurological diseases and the potential of its inhibitors to enter clinical translation, along with its structural and functional aspects |
| 23542362 | SIRT1 is regulated by a NAD(+)-dependent DNA repair enzyme, poly(ADP-ribose) polymerase-1 (PARP1), and subsequent NAD(+) depletion by oxidative stress may have consequent effects on inflammatory and stress responses as well as cellular senescence |
| 23542362 | In this review, the mechanisms of cigarette smoke/oxidant-mediated redox posttranslational modifications of SIRT1 and its roles in PARP1 and NF-kappaB activation, and FOXO3 and eNOS regulation, as well as chromatin remodeling/histone modifications during inflammaging, are discussed |
| 23514618 | Gene array qPCR analysis of MIA PaCa-2 cells treated with the lead compound revealed significant dose-dependent modulation of a distinct subset of genes, including strong induction of DNA damage responsive genes CDKN1A, DDIT3, GADD45A/G, and PPM1D, and repression of genes involved in telomere maintenance, including hPOT1 and PARP1 |
| 23016858 | PARP1 is a valuable therapeutic target, with a central role in responses to DNA damage |
| 22753495 | However, overexpression of SIRT6 in "middle-aged" and presenescent cells strongly stimulated HR repair, and this effect was dependent on mono-ADP ribosylation activity of poly(ADP-ribose) polymerase (PARP1) |
Entries Per Page
Displaying Page of
