HCSGD entry for SREK1
1. General information
| Official gene symbol | SREK1 |
|---|---|
| Entrez ID | 140890 |
| Gene full name | splicing regulatory glutamine/lysine-rich protein 1 |
| Other gene symbols | SFRS12 SRrp508 SRrp86 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005681 | Spliceosomal complex | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006397 | MRNA processing | IEA | biological_process |
| GO:0008380 | RNA splicing | IEA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8597010030 | 0.1903354356 | 0.9999902473 | 0.8457530722 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0208881887 |
| GSE13712_SHEAR | Down | -0.0752296839 |
| GSE13712_STATIC | Down | -0.1918439990 |
| GSE19018 | Up | 0.0101297335 |
| GSE19899_A1 | Down | -0.0199519097 |
| GSE19899_A2 | Down | -0.2629686853 |
| PubMed_21979375_A1 | Down | -0.3744879799 |
| PubMed_21979375_A2 | Down | -0.3278865754 |
| GSE35957 | Up | 0.0621999129 |
| GSE36640 | Down | -0.1351948025 |
| GSE54402 | Down | -0.0844465299 |
| GSE9593 | Down | -0.1342171760 |
| GSE43922 | Up | 0.0131556610 |
| GSE24585 | Up | 0.2801030357 |
| GSE37065 | Up | 0.0946277939 |
| GSE28863_A1 | Up | 0.4822853537 |
| GSE28863_A2 | Up | 0.4149843094 |
| GSE28863_A3 | Down | -0.0017733517 |
| GSE28863_A4 | Down | -0.3133685663 |
| GSE48662 | Down | -0.6409160236 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023706 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-218-5p | MIMAT0000275 | MIRT024232 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030834 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT032150 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
