HCSGD entry for SIRPA
1. General information
| Official gene symbol | SIRPA |
|---|---|
| Entrez ID | 140885 |
| Gene full name | signal-regulatory protein alpha |
| Other gene symbols | BIT CD172A MFR MYD-1 P84 PTPNS1 SHPS1 SIRP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007155 | Cell adhesion | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1138113636 | 0.3278559097 | 0.6939145008 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5810820126 |
| GSE13712_SHEAR | Up | 0.3173769019 |
| GSE13712_STATIC | Down | -0.0505149097 |
| GSE19018 | Down | -0.2635466966 |
| GSE19899_A1 | Down | -0.0628870824 |
| GSE19899_A2 | Up | 0.1571935932 |
| PubMed_21979375_A1 | Up | 0.1767034159 |
| PubMed_21979375_A2 | Up | 0.7615684354 |
| GSE35957 | Up | 0.6983305092 |
| GSE36640 | Up | 0.5925312086 |
| GSE54402 | Down | -0.7507425106 |
| GSE9593 | Up | 0.2424739679 |
| GSE43922 | Up | 0.0153922324 |
| GSE24585 | Down | -0.0873547226 |
| GSE37065 | Up | 0.3491592500 |
| GSE28863_A1 | Down | -0.1123455404 |
| GSE28863_A2 | Down | -0.0727067384 |
| GSE28863_A3 | Up | 0.3060984187 |
| GSE28863_A4 | Up | 0.1100405860 |
| GSE48662 | Up | 0.1867522662 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-17-5p | MIMAT0000070 | MIRT035530 | Luciferase reporter assay | Functional MTI | 23562609 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT035531 | Luciferase reporter assay | Functional MTI | 23562609 |
| hsa-miR-106a-5p | MIMAT0000103 | MIRT035532 | Luciferase reporter assay | Functional MTI | 23562609 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040132 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23801922 | Role of CD47 and Signal Regulatory Protein Alpha (SIRPalpha) in Regulating the Clearance of Viable or Aged Blood Cells |
| 23801922 | The latter mechanism is dependent on the interaction between target cell CD47 and SIRPalpha on the phagocyte |
| 23801922 | In this context, SIRPalpha functions to inhibit prophagocytic signaling from Fcgamma receptors, complement receptors, and LDL receptor-related protein-1 (LRP-1), but not scavenger receptors |
| 23801922 | The expression level and/or distribution of CD47 may be altered on the surface of apoptotic/senescent cells, rendering the phagocytosis inhibitory function of the CD47/SIRPalpha interaction reduced or eliminated |
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