HCSGD entry for CRK
1. General information
| Official gene symbol | CRK |
|---|---|
| Entrez ID | 1398 |
| Gene full name | v-crk sarcoma virus CT10 oncogene homolog (avian) |
| Other gene symbols | CRKII p38 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000186 | Activation of MAPKK activity | TAS | biological_process |
| GO:0005070 | SH3/SH2 adaptor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IC | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0032319 | Regulation of Rho GTPase activity | IDA | biological_process |
| GO:0032956 | Regulation of actin cytoskeleton organization | IDA | biological_process |
| GO:0035020 | Regulation of Rac protein signal transduction | IEA | biological_process |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0042169 | SH2 domain binding | IPI | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045309 | Protein phosphorylated amino acid binding | IEA | molecular_function |
| GO:0046875 | Ephrin receptor binding | IPI | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048013 | Ephrin receptor signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0424149880 | 0.9541676570 | 0.4602090272 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4278090849 |
| GSE13712_SHEAR | Up | 0.1187479165 |
| GSE13712_STATIC | Up | 0.1596463249 |
| GSE19018 | Down | -0.7825678319 |
| GSE19899_A1 | Up | 0.1842674718 |
| GSE19899_A2 | Up | 0.4630388555 |
| PubMed_21979375_A1 | Up | 0.4422374139 |
| PubMed_21979375_A2 | Up | 0.1506088197 |
| GSE35957 | Down | -0.0316229048 |
| GSE36640 | Up | 0.2826207816 |
| GSE54402 | Up | 0.3808766807 |
| GSE9593 | Up | 0.4916424204 |
| GSE43922 | Up | 0.1586568455 |
| GSE24585 | Up | 0.4709273511 |
| GSE37065 | Down | -0.0923644750 |
| GSE28863_A1 | Up | 0.0298621035 |
| GSE28863_A2 | Down | -0.0899418156 |
| GSE28863_A3 | Down | -0.4012979819 |
| GSE28863_A4 | Up | 0.2782436897 |
| GSE48662 | Up | 0.2743707709 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-126-3p | MIMAT0000445 | MIRT002993 | Luciferase reporter assay//Western blot//qRT-PCR | Functional MTI | 18602365 |
| hsa-miR-126-3p | MIMAT0000445 | MIRT002993 | Western blot | Functional MTI | 19767772 |
| hsa-miR-126-3p | MIMAT0000445 | MIRT002993 | Immunohistochemistry//Luciferase reporter assay//Western blot | Functional MTI | 20619534 |
| hsa-miR-126-3p | MIMAT0000445 | MIRT002993 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT007166 | Luciferase reporter assay | Functional MTI | 23184980 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT007166 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT021297 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024820 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT025620 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026885 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-106b-3p | MIMAT0004672 | MIRT038548 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-129-1-3p | MIMAT0004548 | MIRT038706 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046474 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051574 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052687 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
