HCSGD entry for CRH

1. General information

Official gene symbolCRH
Entrez ID1392
Gene full namecorticotropin releasing hormone
Other gene symbolsCRF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001934Positive regulation of protein phosphorylationIEAbiological_process
GO:0001963Synaptic transmission, dopaminergicIDAbiological_process
GO:0005102Receptor bindingTASmolecular_function
GO:0005179Hormone activityTASmolecular_function
GO:0005184Neuropeptide hormone activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006704Glucocorticoid biosynthetic processIEAbiological_process
GO:0006954Inflammatory responseIDAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007565Female pregnancyIDAbiological_process
GO:0007567ParturitionTASbiological_process
GO:0007611Learning or memoryTASbiological_process
GO:0007616Long-term memoryIEAbiological_process
GO:0007631Feeding behaviorIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008306Associative learningIEAbiological_process
GO:0008628Hormone-mediated apoptotic signaling pathwayIEAbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0010700Negative regulation of norepinephrine secretionIEAbiological_process
GO:0010841Positive regulation of circadian sleep/wake cycle, wakefulnessNASbiological_process
GO:0010942Positive regulation of cell deathIEAbiological_process
GO:0014062Regulation of serotonin secretionIEAbiological_process
GO:0016101Diterpenoid metabolic processIEAbiological_process
GO:0017045Corticotropin-releasing hormone activityIEAmolecular_function
GO:0021854Hypothalamus developmentIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0030325Adrenal gland developmentIEAbiological_process
GO:0030819Positive regulation of cAMP biosynthetic processIEAbiological_process
GO:0032811Negative regulation of epinephrine secretionIEAbiological_process
GO:0033494Ferulate metabolic processIEAbiological_process
GO:0033685Negative regulation of luteinizing hormone secretionIEAbiological_process
GO:0035641Locomotory exploration behaviorIEAbiological_process
GO:0035774Positive regulation of insulin secretion involved in cellular response to glucose stimulusIEAbiological_process
GO:0035902Response to immobilization stressIEAbiological_process
GO:0042322Negative regulation of circadian sleep/wake cycle, REM sleepNASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043196VaricosityIEAcellular_component
GO:0043204PerikaryonIEAcellular_component
GO:0043627Response to estrogenIEAbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045472Response to etherIEAbiological_process
GO:0045776Negative regulation of blood pressureIEAbiological_process
GO:0048265Response to painIEAbiological_process
GO:0050801Ion homeostasisIEAbiological_process
GO:0051412Response to corticosteroneIEAbiological_process
GO:0051430Corticotropin-releasing hormone receptor 1 bindingIEAmolecular_function
GO:0051431Corticotropin-releasing hormone receptor 2 bindingIEAmolecular_function
GO:0051461Positive regulation of corticotropin secretionIEAbiological_process
GO:0051464Positive regulation of cortisol secretionIDAbiological_process
GO:0060291Long-term synaptic potentiationIEAbiological_process
GO:0060456Positive regulation of digestive system processIEAbiological_process
GO:0060548Negative regulation of cell deathIEAbiological_process
GO:0070093Negative regulation of glucagon secretionIEAbiological_process
GO:0071314Cellular response to cocaineIEAbiological_process
GO:0071549Cellular response to dexamethasone stimulusIEAbiological_process
GO:0090280Positive regulation of calcium ion importIEAbiological_process
GO:2000310Regulation of N-methyl-D-aspartate selective glutamate receptor activityIDAbiological_process
GO:2000854Positive regulation of corticosterone secretionIEAbiological_process
GO:2000987Positive regulation of behavioral fear responseIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.70647070400.67046706430.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0883004592
GSE13712_SHEARDown-0.0601736427
GSE13712_STATICDown-0.0702694407
GSE19018Up0.2369104627
GSE19899_A1Down-0.0061945867
GSE19899_A2Up0.2628550451
PubMed_21979375_A1Down-0.3604721273
PubMed_21979375_A2Down-0.3485763573
GSE35957Up0.0438675078
GSE36640Up0.0196920996
GSE54402Up0.0707063735
GSE9593Up0.1144920830
GSE43922Up0.0115638150
GSE24585Down-0.1448348558
GSE37065Up0.0185500565
GSE28863_A1Down-0.1754293685
GSE28863_A2Up0.0143511328
GSE28863_A3Up0.3113629622
GSE28863_A4Up0.2234271025
GSE48662Down-0.0095602351

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

D-PhenylalanineDB02556 EXPT01257
Alpha-Aminoisobutyric AcidDB02952 EXPT00471

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-142-3pMIMAT0000434MIRT021551MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26371764In the HIPP of MDD subjects, several genes involved in neuroprotection and in stress response (FKBP5, CRH) showed altered levels of mRNA
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