HCSGD entry for NACC2
1. General information
| Official gene symbol | NACC2 |
|---|---|
| Entrez ID | 138151 |
| Gene full name | NACC family member 2, BEN and BTB (POZ) domain containing |
| Other gene symbols | BEND9 BTBD14 BTBD14A BTBD31 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IDA | molecular_function |
| GO:0001076 | RNA polymerase II transcription factor binding transcription factor activity | IDA | molecular_function |
| GO:0001078 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | IDA | molecular_function |
| GO:0004407 | Histone deacetylase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0006476 | Protein deacetylation | IDA | biological_process |
| GO:0008152 | Metabolic process | IDA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | ISS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0010608 | Posttranscriptional regulation of gene expression | IMP | biological_process |
| GO:0016575 | Histone deacetylation | IDA | biological_process |
| GO:0016581 | NuRD complex | IDA | cellular_component |
| GO:0016604 | Nuclear body | ISS | cellular_component |
| GO:0034629 | Cellular protein complex localization | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0042826 | Histone deacetylase binding | IPI | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0051260 | Protein homooligomerization | ISS | biological_process |
| GO:1900477 | Negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:1902231 | Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1069722655 | 0.7477373352 | 0.6794442568 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3331292930 |
| GSE13712_SHEAR | Up | 0.0516403595 |
| GSE13712_STATIC | Up | 0.5306492378 |
| GSE19018 | Down | -0.3191344195 |
| GSE19899_A1 | Down | -0.0796676535 |
| GSE19899_A2 | Up | 1.1374931122 |
| PubMed_21979375_A1 | Down | -0.1025903885 |
| PubMed_21979375_A2 | Up | 0.6418619140 |
| GSE35957 | Up | 0.1841166363 |
| GSE36640 | Up | 0.5340441426 |
| GSE54402 | Up | 0.1130361940 |
| GSE9593 | Up | 0.1837997426 |
| GSE43922 | Down | -0.0900207014 |
| GSE24585 | Up | 0.3384645213 |
| GSE37065 | Down | -0.1996372311 |
| GSE28863_A1 | Up | 0.0450826587 |
| GSE28863_A2 | Down | -0.0541655128 |
| GSE28863_A3 | Up | 0.3235397722 |
| GSE28863_A4 | Up | 0.0679203257 |
| GSE48662 | Down | -0.0049405989 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-423-3p | MIMAT0001340 | MIRT016683 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020125 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT023430 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT027987 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028773 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031107 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040661 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047631 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049121 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
