HCSGD entry for ADORA2B

1. General information

Official gene symbolADORA2B
Entrez ID136
Gene full nameadenosine A2b receptor
Other gene symbolsADORA2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0001609G-protein coupled adenosine receptor activityIEAmolecular_function
GO:0002882Positive regulation of chronic inflammatory response to non-antigenic stimulusIEAbiological_process
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006968Cellular defense responseTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007190Activation of adenylate cyclase activityTASbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0007588ExcretionTASbiological_process
GO:0010575Positive regulation vascular endothelial growth factor productionIEAbiological_process
GO:0030828Positive regulation of cGMP biosynthetic processIEAbiological_process
GO:0031284Positive regulation of guanylate cyclase activityIEAbiological_process
GO:0031668Cellular response to extracellular stimulusIEAbiological_process
GO:0032722Positive regulation of chemokine productionIEAbiological_process
GO:0032755Positive regulation of interleukin-6 productionIEAbiological_process
GO:0043306Positive regulation of mast cell degranulationIEAbiological_process
GO:0060087Relaxation of vascular smooth muscleIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02215022610.18192842220.35641662590.8270378215

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1745870071
GSE13712_SHEARUp0.5411242850
GSE13712_STATICUp1.1926800410
GSE19018Up0.4067600459
GSE19899_A1Down-0.2868984558
GSE19899_A2Up0.6831120934
PubMed_21979375_A1Up1.5908434742
PubMed_21979375_A2Up2.1150570205
GSE35957Down-2.3676085540
GSE36640Down-1.0314256843
GSE54402Down-1.5701676322
GSE9593Up0.5485947182
GSE43922Up0.0331341728
GSE24585Up0.0699802599
GSE37065Down-0.1027785447
GSE28863_A1Up0.0228206481
GSE28863_A2Up0.3389130986
GSE28863_A3Up0.1422102332
GSE28863_A4Up0.0579578431
GSE48662Up0.2779207424

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TheophyllineDB00277 APRD00082 | DB09359
EnprofyllineDB00824 APRD00273
DefibrotideDB04932 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-27b-3pMIMAT0000419MIRT004499qRT-PCR//Luciferase reporter assayFunctional MTI20388705
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.