HCSGD entry for IL31RA
1. General information
| Official gene symbol | IL31RA |
|---|---|
| Entrez ID | 133396 |
| Gene full name | interleukin 31 receptor A |
| Other gene symbols | CRL CRL3 GLM-R GLMR GPL IL-31RA PLCA2 PRO21384 hGLM-R |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | NAS | biological_process |
| GO:0003713 | Transcription coactivator activity | NAS | molecular_function |
| GO:0004896 | Cytokine receptor activity | TAS | molecular_function |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006952 | Defense response | NAS | biological_process |
| GO:0007169 | Transmembrane receptor protein tyrosine kinase signaling pathway | NAS | biological_process |
| GO:0007259 | JAK-STAT cascade | IEP | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IDA | biological_process |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0019901 | Protein kinase binding | NAS | molecular_function |
| GO:0019955 | Cytokine binding | NAS | molecular_function |
| GO:0030224 | Monocyte differentiation | IEP | biological_process |
| GO:0030225 | Macrophage differentiation | NAS | biological_process |
| GO:0042517 | Positive regulation of tyrosine phosphorylation of Stat3 protein | IEP | biological_process |
| GO:0042523 | Positive regulation of tyrosine phosphorylation of Stat5 protein | IEP | biological_process |
| GO:0042592 | Homeostatic process | NAS | biological_process |
| GO:0043031 | Negative regulation of macrophage activation | NAS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | NAS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0138531705 | 0.9849514684 | 0.2937043965 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1067587337 |
| GSE13712_SHEAR | Up | 0.7445598052 |
| GSE13712_STATIC | Up | 1.2654975993 |
| GSE19018 | Down | -0.0932768572 |
| GSE19899_A1 | Up | 0.3225457043 |
| GSE19899_A2 | Up | 0.1269717112 |
| PubMed_21979375_A1 | Up | 0.6390137170 |
| PubMed_21979375_A2 | Up | 1.0539867243 |
| GSE35957 | Down | -0.0790075610 |
| GSE36640 | Up | 0.2913083983 |
| GSE54402 | Up | 0.4848744302 |
| GSE9593 | Up | 0.2794847892 |
| GSE43922 | Up | 1.0994476388 |
| GSE24585 | Down | -0.1998092466 |
| GSE37065 | Down | -0.1514178326 |
| GSE28863_A1 | Down | -0.0917046499 |
| GSE28863_A2 | Up | 0.3064507402 |
| GSE28863_A3 | Up | 0.1760571690 |
| GSE28863_A4 | Up | 0.0504029338 |
| GSE48662 | Down | -0.0161820088 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019063 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25782162 | Here, we report that MLN4924 specifically inhibited protein neddylation, inactivated cullin-RING E3 ligase (CRL), the best-known neddylation substrate, and induced the accumulation of tumor-suppressive CRL substrates in lymphoma cells |
| 22965024 | Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis |
| 22965024 | RBX1/ROC1 is an essential subunit of the largest multiunit Cullin-RING E3 ligase (CRL), which controls the degradation of diverse substrates, thereby regulating numerous cellular processes |
| 22965024 | Interestingly, independent of senescence, RBX1 knockdown also triggers an autophagy response, due, at least in part, to the accumulation of the MTOR-inhibitory protein DEPTOR, a recently identified CRL substrate |
| 22965024 | Similar observations were also made in many types of human cancer cells upon inhibition of CRL by MLN4924 |
| 4083160 | Cell and DNA replicative potentials were studied in 10 strains of skin fibroblasts from unrelated patients with the Werner syndrome (WS) and in a progeric CRL 1277 strain |
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