HCSGD entry for COX5B

1. General information

Official gene symbolCOX5B
Entrez ID1329
Gene full namecytochrome c oxidase subunit Vb
Other gene symbolsCOXVB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004129Cytochrome-c oxidase activityIEAmolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005743Mitochondrial inner membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0006812Cation transportTASbiological_process
GO:0007585Respiratory gaseous exchangeTASbiological_process
GO:0015672Monovalent inorganic cation transportTASbiological_process
GO:0022904Respiratory electron transport chainTASbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0044237Cellular metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0055085Transmembrane transportTASbiological_process
GO:1902600Hydrogen ion transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31637460580.76150493900.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1278640269
GSE13712_SHEARDown-0.0419673599
GSE13712_STATICDown-0.0555965403
GSE19018Up0.5724360020
GSE19899_A1Up0.0574544814
GSE19899_A2Up0.3986112059
PubMed_21979375_A1Up0.2028160831
PubMed_21979375_A2Up0.4256433885
GSE35957Up0.1305718429
GSE36640Down-0.0280427172
GSE54402Up0.1911509871
GSE9593Down-0.0793821496
GSE43922Down-0.0847211947
GSE24585Down-0.1504929784
GSE37065Up0.1700207138
GSE28863_A1Down-0.1783981835
GSE28863_A2Up0.0571194625
GSE28863_A3Down-0.1347676869
GSE28863_A4Down-0.1527714588
GSE48662Down-0.0028805361

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Cholic AcidDB02659 EXPT00906
N-FormylmethionineDB04464 EXPT01455

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26506233Loss of COX5B inhibits proliferation and promotes senescence via mitochondrial dysfunction in breast cancer
26506233COX5B, a peripheral subunit of the cytochrome c oxidase complex, has previously been reported to maintain the stability of this complex
26506233Here, by performing SILAC assays in breast cancer cell models and detecting COX5B expression in tissues, we found that COX5B expression was elevated in breast cancer
26506233Down-regulation of COX5B in breast cancer cell lines can suppress cell proliferation and induced cell senescence which was accompanied by elevating production of IL-8 and other cytokines
26506233Mechanistic studies reveal that COX5B silence induces an increase in production of ROS, depolarization of MMP and a decrease in ATP
26506233What's more, silence of COX5B leads to metabolic disorders, such as increased glucose uptake and decreased lactate secretion
26506233Collectively, our study shows that loss of COX5B induces mitochondrial dysfunction and subsequently leads to cell growth suppression and cell senescence
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