HCSGD entry for ADK

1. General information

Official gene symbolADK
Entrez ID132
Gene full nameadenosine kinase
Other gene symbolsAK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004001Adenosine kinase activityEXPmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006144Purine nucleobase metabolic processTASbiological_process
GO:0006166Purine ribonucleoside salvageIEAbiological_process
GO:0006175DATP biosynthetic processIEAbiological_process
GO:0009156Ribonucleoside monophosphate biosynthetic processTASbiological_process
GO:0010613Positive regulation of cardiac muscle hypertrophyIEAbiological_process
GO:0016773Phosphotransferase activity, alcohol group as acceptorIEAmolecular_function
GO:0032922Circadian regulation of gene expressionIEAbiological_process
GO:0042102Positive regulation of T cell proliferationIEAbiological_process
GO:0043101Purine-containing compound salvageTASbiological_process
GO:0044209AMP salvageIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0044342Type B pancreatic cell proliferationIEAbiological_process
GO:0046085Adenosine metabolic processIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00738737130.90744315190.22478959541.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.8260765636
GSE13712_SHEARUp0.2648449210
GSE13712_STATICUp0.4108206613
GSE19018Up1.2476625006
GSE19899_A1Up1.0212042618
GSE19899_A2Up0.3618730276
PubMed_21979375_A1Up1.0002401825
PubMed_21979375_A2Down-0.2301458734
GSE35957Down-0.2100896631
GSE36640Up0.0028328641
GSE54402Up0.9146603721
GSE9593Down-0.1279020324
GSE43922Down-0.0418015700
GSE24585Down-0.0196794558
GSE37065Up0.2015620956
GSE28863_A1Up0.2537925224
GSE28863_A2Up0.1730970543
GSE28863_A3Down-0.3485047030
GSE28863_A4Up0.1819763025
GSE48662Down-0.3756034598

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

RibavirinDB00811 APRD00081 | EXPT02825 | DB01693
7-(5-DEOXY-BETA-D-RIBOFURANOSYL)-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINEDB07173 -
5-[4-(DIMETHYLAMINO)PHENYL]-6-[(6-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYNYL]PYRIMIDIN-4-AMINEDB07280 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT051111CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.