HCSGD entry for TRIM71
1. General information
| Official gene symbol | TRIM71 |
|---|---|
| Entrez ID | 131405 |
| Gene full name | tripartite motif containing 71, E3 ubiquitin protein ligase |
| Other gene symbols | LIN-41 LIN41 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | ISS | biological_process |
| GO:0000932 | Cytoplasmic mRNA processing body | ISS | cellular_component |
| GO:0001843 | Neural tube closure | IEA | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | ISS | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | ISS | biological_process |
| GO:0010586 | MiRNA metabolic process | ISS | biological_process |
| GO:0021915 | Neural tube development | ISS | biological_process |
| GO:0035198 | MiRNA binding | ISS | molecular_function |
| GO:0035278 | Negative regulation of translation involved in gene silencing by miRNA | ISS | biological_process |
| GO:0051865 | Protein autoubiquitination | ISS | biological_process |
| GO:0060964 | Regulation of gene silencing by miRNA | ISS | biological_process |
| GO:0072089 | Stem cell proliferation | ISS | biological_process |
| GO:2000177 | Regulation of neural precursor cell proliferation | ISS | biological_process |
| GO:2000637 | Positive regulation of gene silencing by miRNA | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8930991984 | 0.3951280384 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1141800561 |
| GSE13712_SHEAR | Down | -0.1165106609 |
| GSE13712_STATIC | Up | 0.0692275947 |
| GSE19018 | Up | 0.0812940922 |
| GSE19899_A1 | Down | -0.0064080668 |
| GSE19899_A2 | Down | -0.1969053338 |
| PubMed_21979375_A1 | Down | -0.1069917082 |
| PubMed_21979375_A2 | Up | 0.0452753628 |
| GSE35957 | Up | 0.0739024386 |
| GSE36640 | Up | 0.1956605732 |
| GSE54402 | Down | -0.0827549272 |
| GSE9593 | Up | 0.0458831987 |
| GSE43922 | Up | 0.1098595481 |
| GSE24585 | Up | 0.0065875123 |
| GSE37065 | Down | -0.0768887226 |
| GSE28863_A1 | Down | -0.2252125055 |
| GSE28863_A2 | Down | -0.1286988437 |
| GSE28863_A3 | Up | 0.1227633646 |
| GSE28863_A4 | Down | -0.1066426317 |
| GSE48662 | Down | -0.0477054344 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7c-5p | MIMAT0000064 | MIRT002076 | Luciferase reporter assay//Reporter assay;Other | Functional MTI | 17890240 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT002077 | Luciferase reporter assay//Reporter assay | Functional MTI | 17890240 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT002077 | Luciferase reporter assay | Functional MTI | 18829576 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT051040 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-let-7a-5p | MIMAT0000062 | 1 | hsa-let-7a | 17890240 | |||
| hsa-let-7a-5p | MIMAT0000062 | 2 | hsa-let-7a | 17890240 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
