HCSGD entry for COL4A3

1. General information

Official gene symbolCOL4A3
Entrez ID1285
Gene full namecollagen, type IV, alpha 3 (Goodpasture antigen)
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005178Integrin bindingIDA TASmolecular_function
GO:0005198Structural molecule activityNASmolecular_function
GO:0005201Extracellular matrix structural constituentIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005587Collagen type IVIDAcellular_component
GO:0005604Basement membraneIDAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayNASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007605Sensory perception of soundTASbiological_process
GO:0008015Blood circulationTASbiological_process
GO:0008191Metalloendopeptidase inhibitor activityNASmolecular_function
GO:0008283Cell proliferationIDAbiological_process
GO:0008285Negative regulation of cell proliferationTASbiological_process
GO:0010466Negative regulation of peptidase activityNASbiological_process
GO:0010951Negative regulation of endopeptidase activityNASbiological_process
GO:0016525Negative regulation of angiogenesisIDAbiological_process
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030574Collagen catabolic processTASbiological_process
GO:0032836Glomerular basement membrane developmentISSbiological_process
GO:0043086Negative regulation of catalytic activityNASbiological_process
GO:0072577Endothelial cell apoptotic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.32123294710.92767727290.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0442792743
GSE13712_SHEARUp0.0122062710
GSE13712_STATICDown-0.0585473811
GSE19018Up0.0569857913
GSE19899_A1Up0.1346920320
GSE19899_A2Up0.0473916519
PubMed_21979375_A1Up0.0962198832
PubMed_21979375_A2Down-0.0336902357
GSE35957Up1.7528687020
GSE36640Down-0.0106040961
GSE54402Down-0.0141967468
GSE9593Down-0.0978230496
GSE43922Up0.0214473926
GSE24585Up0.0618842173
GSE37065Down-0.0022250526
GSE28863_A1Down-0.0905096227
GSE28863_A2Up0.0698775729
GSE28863_A3Up0.0975136924
GSE28863_A4Up0.0748244149
GSE48662Up0.3125433927

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-10a-5pMIMAT0000253MIRT047553CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22829758These include COL4A3, CFLAR, GULP1, PDCD1, CASP10, PAX3, BOK, HSPD1, PITX2, and PML
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