HCSGD entry for COL4A2
1. General information
| Official gene symbol | COL4A2 |
|---|---|
| Entrez ID | 1284 |
| Gene full name | collagen, type IV, alpha 2 |
| Other gene symbols | ICH POREN2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0005201 | Extracellular matrix structural constituent | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005587 | Collagen type IV | IEA TAS | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0016525 | Negative regulation of angiogenesis | IDA | biological_process |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | NAS TAS | biological_process |
| GO:0030574 | Collagen catabolic process | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IDA ISS TAS | cellular_component |
| GO:0071560 | Cellular response to transforming growth factor beta stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9531958740 | 0.0001935945 | 0.9999902473 | 0.0248226415 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -2.8644369971 |
| GSE13712_SHEAR | Down | -0.1192145599 |
| GSE13712_STATIC | Down | -0.1473768100 |
| GSE19018 | Up | 0.3214580462 |
| GSE19899_A1 | Down | -1.8199943736 |
| GSE19899_A2 | Down | -2.2418037940 |
| PubMed_21979375_A1 | Down | -2.1162308209 |
| PubMed_21979375_A2 | Down | -1.7570560887 |
| GSE35957 | Down | -0.2932154958 |
| GSE36640 | Up | 0.0976314199 |
| GSE54402 | Down | -2.1928768648 |
| GSE9593 | Down | -0.1809111018 |
| GSE43922 | Down | -0.5486520936 |
| GSE24585 | Down | -0.6196613245 |
| GSE37065 | Down | -0.3848343449 |
| GSE28863_A1 | Down | -0.2373778419 |
| GSE28863_A2 | Down | -0.5133575241 |
| GSE28863_A3 | Up | 0.1192525062 |
| GSE28863_A4 | Up | 0.0210243506 |
| GSE48662 | Up | 0.0005279992 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | MIRT001926 | Luciferase reporter assay//Reporter assay;Other | Functional MTI | 18390668 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT003220 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20067797 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT003220 | qRT-PCR | Functional MTI (Weak) | 22864815 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020729 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029546 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040463 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047706 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049302 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051129 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | 2 | hsa-miR-29c | 18390668 | |||
| hsa-miR-29c-3p | MIMAT0000681 | 1 | hsa-miR-29c | 18390668 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
