HCSGD entry for COL3A1

1. General information

Official gene symbolCOL3A1
Entrez ID1281
Gene full namecollagen, type III, alpha 1
Other gene symbolsEDS4A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentIEAbiological_process
GO:0001568Blood vessel developmentIEAbiological_process
GO:0005178Integrin bindingIMP NASmolecular_function
GO:0005201Extracellular matrix structural constituentIEA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005581CollagenIEAcellular_component
GO:0005586Collagen type IIIIMP NAScellular_component
GO:0005615Extracellular spaceIDA NAScellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0007160Cell-matrix adhesionIDAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIDAbiological_process
GO:0007229Integrin-mediated signaling pathwayIMPbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007507Heart developmentIMPbiological_process
GO:0007568AgingIEAbiological_process
GO:0009314Response to radiationIDAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0018149Peptide cross-linkingIDAbiological_process
GO:0021987Cerebral cortex developmentISSbiological_process
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030168Platelet activationNASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030199Collagen fibril organizationIMP NASbiological_process
GO:0030574Collagen catabolic processTASbiological_process
GO:0031012Extracellular matrixIMP TAScellular_component
GO:0034097Response to cytokineIDAbiological_process
GO:0035025Positive regulation of Rho protein signal transductionISSbiological_process
GO:0042060Wound healingIDA NASbiological_process
GO:0043206Extracellular fibril organizationIMPbiological_process
GO:0043588Skin developmentIMPbiological_process
GO:0046332SMAD bindingIEAmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048407Platelet-derived growth factor bindingIDAmolecular_function
GO:0048565Digestive tract developmentIEAbiological_process
GO:0050777Negative regulation of immune responseIMPbiological_process
GO:0071230Cellular response to amino acid stimulusIEAbiological_process
GO:2001223Negative regulation of neuron migrationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.25858130770.00004037080.95225734660.0109660000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6783792394
GSE13712_SHEARDown-1.9842483004
GSE13712_STATICDown-1.7233734341
GSE19018Down-0.6269566184
GSE19899_A1Down-2.0504792263
GSE19899_A2Down-4.0029192338
PubMed_21979375_A1Down-4.3477860169
PubMed_21979375_A2Down-3.7272180079
GSE35957Down-0.0573823113
GSE36640Down-0.5350823281
GSE54402Down-1.9027054508
GSE9593Down-0.2821719938
GSE43922Down-1.8142830123
GSE24585Up0.0514169780
GSE37065Down-0.4242028080
GSE28863_A1Up2.1137425196
GSE28863_A2Up1.7945962041
GSE28863_A3Up0.7548306872
GSE28863_A4Down-0.3880679141
GSE48662Down-0.3978898439

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Collagenase clostridium histolyticumDB00048 BTD00010 | BIOD00010

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29c-3pMIMAT0000681MIRT000927Luciferase reporter assay//Reporter assay;OtherFunctional MTI18390668
hsa-miR-29b-3pMIMAT0000100MIRT005567Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20657750
hsa-miR-335-5pMIMAT0000765MIRT018299MicroarrayFunctional MTI (Weak)18185580
hsa-miR-455-3pMIMAT0004784MIRT037808CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-29c-3pMIMAT00006811hsa-miR-29c18390668
hsa-miR-29c-3pMIMAT00006813hsa-miR-29c18390668
hsa-miR-29c-3pMIMAT00006812hsa-miR-29c18390668
hsa-miR-29a-3pMIMAT0000086NAhsa-miR-29a20201077
hsa-miR-29b-3pMIMAT0000100NAhsa-miR-29b20201077
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23030720The mRNA levels of MMP-1, MMP-3 and type I (alpha1) collagen were determined by quantitative real-time PCR
9597752The over-expressing clones showed a decrease in proliferation and displayed the differentiation-related phenotypes such as increased basal levels of alpha (I) collagen mRNA expression and high inducibility by R
9597752Conversely, introduction of hic-5 anti-sense vector leads to the inhibition of alpha (I) collagen mRNA following induction by R
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