HCSGD entry for COL2A1

1. General information

Official gene symbolCOL2A1
Entrez ID1280
Gene full namecollagen, type II, alpha 1
Other gene symbolsANFH AOM COL11A3 SEDC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentIMPbiological_process
GO:0001502Cartilage condensationIEAbiological_process
GO:0001894Tissue homeostasisIEAbiological_process
GO:0001958Endochondral ossificationIEAbiological_process
GO:0002062Chondrocyte differentiationIEAbiological_process
GO:0003007Heart morphogenesisIEAbiological_process
GO:0005576Extracellular regionTAScellular_component
GO:0005585Collagen type IIIDAcellular_component
GO:0005604Basement membraneIEAcellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0006029Proteoglycan metabolic processIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007417Central nervous system developmentIEAbiological_process
GO:0007601Visual perceptionIMPbiological_process
GO:0007605Sensory perception of soundIMPbiological_process
GO:0010468Regulation of gene expressionIEAbiological_process
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030020Extracellular matrix structural constituent conferring tensile strengthICmolecular_function
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030199Collagen fibril organizationIMPbiological_process
GO:0030574Collagen catabolic processTASbiological_process
GO:0030903Notochord developmentIEAbiological_process
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0042802Identical protein bindingNASmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048407Platelet-derived growth factor bindingIDAmolecular_function
GO:0051216Cartilage developmentTASbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060174Limb bud formationIEAbiological_process
GO:0060272Embryonic skeletal joint morphogenesisIMPbiological_process
GO:0060351Cartilage development involved in endochondral bone morphogenesisIEAbiological_process
GO:0071599Otic vesicle developmentIEAbiological_process
GO:0071773Cellular response to BMP stimulusIEAbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.72458188900.65937990960.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0376060868
GSE13712_SHEARUp0.0225915126
GSE13712_STATICUp0.0383991868
GSE19018Up0.1942970441
GSE19899_A1Up0.0268250518
GSE19899_A2Up0.0530722915
PubMed_21979375_A1Down-0.0536221790
PubMed_21979375_A2Down-0.1095537890
GSE35957Up0.0885066892
GSE36640Down-0.1093136424
GSE54402Down-0.0914517092
GSE9593Down-0.2455752659
GSE43922Down-0.0122111154
GSE24585Up0.1821385450
GSE37065Down-0.2814319075
GSE28863_A1Down-0.0967304310
GSE28863_A2Down-0.0371687538
GSE28863_A3Up0.4551148889
GSE28863_A4Up0.1361791284
GSE48662Down-0.0482376498

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Collagenase clostridium histolyticumDB00048 BTD00010 | BIOD00010

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-106a-5pMIMAT0000103MIRT048314CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-29a-3pMIMAT00000861hsa-miR-29a{Western blot}{overexpression by miRNA mimics tranfection}21665270
hsa-miR-29b-3pMIMAT00001001hsa-miR-29b{Western blot}{overexpression by miRNA mimics tranfection}21665270
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24658599The results were supported by data obtained from an AOM/DSS (azoxymethane/dextran sodium sulphate) colon cancer mouse model and from human colon cancer biopsy specimens colonised by pks+ E
22454193The expression levels of mRNAs encoding aggrecan (ACAN), a major structural proteoglycan, type II collagen (COL2A1), and metalloproteinases (MMP) -1, -3, and -13, respectively, were determined using real-time PCR
22454193RESULTS: Chondrocytes stimulated by IL-1beta showed increased MMP-1, MMP-3, and MMP-13 levels, whereas the expression of COL2A1 and ACAN decreased
22454193However, in cells co-treated with IL-1beta and Rg3, the levels of MMP-1 and MMP-13 were lower than in cells treated with IL-1beta alone, and COL2A1 and ACAN expression levels recovered from the low values seen when cultured only in the presence of IL-1beta
19747991INTRODUCTION: Once non-traumatic avascular necrosis of the femoral head (ANFH) happened, vascular impairment and feeble collateral circulation are followed by poor outcomes
19747991We investigated whether abnormalities in EPCs levels and functions are present in ANFH patients
19747991METHODS: 54 ANFH patients were enrolled, including steroid-induced (n=21), alcohol-induced (n=15) and idiopathic ANFH (n=18), and 30 healthy subjects as control (HC)
19747991RESULTS: Mean numbers of circulating EPC were 1460+/-265 cells/ml in HC, 545+/-177 in ANFH, (P<0
19747991In addition, EPCs from ANFH patients showed reduced migratory capacity and increased cellular senescence compared with EPCs from normal subjects, furthermore the ability of angiogenesis in vitro was also impaired
19747991CONCLUSION: Circulating endothelial progenitor cells (EPCs) numbers and functions are reduced in ANFH patients, suggesting that risk factors of ANFH may alter EPCs biology in angiogenesis and vascular repair
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