HCSGD entry for COL1A2
1. General information
| Official gene symbol | COL1A2 |
|---|---|
| Entrez ID | 1278 |
| Gene full name | collagen, type I, alpha 2 |
| Other gene symbols | OI4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001501 | Skeletal system development | IMP | biological_process |
| GO:0001568 | Blood vessel development | IMP | biological_process |
| GO:0005201 | Extracellular matrix structural constituent | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005584 | Collagen type I | IDA IMP TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | IDA | biological_process |
| GO:0007266 | Rho protein signal transduction | IDA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008217 | Regulation of blood pressure | IMP | biological_process |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030199 | Collagen fibril organization | IMP | biological_process |
| GO:0030574 | Collagen catabolic process | TAS | biological_process |
| GO:0030674 | Protein binding, bridging | IMP | molecular_function |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0042476 | Odontogenesis | NAS | biological_process |
| GO:0042802 | Identical protein binding | IDA | molecular_function |
| GO:0043589 | Skin morphogenesis | IMP | biological_process |
| GO:0046332 | SMAD binding | IEA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048407 | Platelet-derived growth factor binding | IDA | molecular_function |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
| GO:0070208 | Protein heterotrimerization | IEA | biological_process |
| GO:0071230 | Cellular response to amino acid stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9634928574 | 0.0002285172 | 0.9999902473 | 0.0265215859 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2890210639 |
| GSE13712_SHEAR | Down | -4.1084286948 |
| GSE13712_STATIC | Down | -4.4640799145 |
| GSE19018 | Down | -0.0253352457 |
| GSE19899_A1 | Down | -1.8667272964 |
| GSE19899_A2 | Down | -1.9388193819 |
| PubMed_21979375_A1 | Down | -2.0697553355 |
| PubMed_21979375_A2 | Down | -1.5366413450 |
| GSE35957 | Down | -0.0722258587 |
| GSE36640 | Down | -0.0049457769 |
| GSE54402 | Down | -1.3828621651 |
| GSE9593 | Down | -0.2487562347 |
| GSE43922 | Down | -1.1435305448 |
| GSE24585 | Up | 0.0146075597 |
| GSE37065 | Down | -0.7384713666 |
| GSE28863_A1 | Up | 0.4558180243 |
| GSE28863_A2 | Up | 0.3167005184 |
| GSE28863_A3 | Up | 0.2513975432 |
| GSE28863_A4 | Down | -0.1753347328 |
| GSE48662 | Down | -0.2456279939 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Collagenase clostridium histolyticum | DB00048 | BTD00010 | BIOD00010 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7g-5p | MIMAT0000414 | MIRT000472 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 20338660 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT001928 | Luciferase reporter assay//Reporter assay;Other | Functional MTI | 18390668 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | NA | hsa-miR-29c | 18390668 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22566095 | Replicative senescent dermal fibroblasts also expressed significantly reduced levels of type I procollagen and increased levels of MMP-1 |
| 11037877 | METHODS: We examined age-related changes in cellular activity (alkaline phosphatase activity, osteocalcin and C-terminal type I procollagen secretion, and cAMP response to parathyroid hormone), replicative capacity, and senescent cell expression in osteoblasts from periarticular bone samples obtained from 15 patients with RA and 15 age-matched patients with osteoarthritis (OA) |
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