HCSGD entry for CNP

1. General information

Official gene symbolCNP
Entrez ID1267
Gene full name2',3'-cyclic nucleotide 3' phosphodiesterase
Other gene symbolsCNP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000226Microtubule cytoskeleton organizationIEAbiological_process
GO:0003723RNA bindingIEAmolecular_function
GO:00041132',3'-cyclic-nucleotide 3'-phosphodiesterase activityIEAmolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005741Mitochondrial outer membraneIEAcellular_component
GO:0005743Mitochondrial inner membraneIEAcellular_component
GO:0005874MicrotubuleIDAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0005902MicrovillusIEAcellular_component
GO:0007268Synaptic transmissionTASbiological_process
GO:0007409AxonogenesisIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0008344Adult locomotory behaviorIEAbiological_process
GO:0009214Cyclic nucleotide catabolic processIEAbiological_process
GO:0009636Response to toxic substanceIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0030551Cyclic nucleotide bindingIEAmolecular_function
GO:0030900Forebrain developmentIEAbiological_process
GO:0031143PseudopodiumIEAcellular_component
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0035748Myelin sheath abaxonal regionIEAcellular_component
GO:0035749Myelin sheath adaxonal regionIEAcellular_component
GO:0042470MelanosomeIEAcellular_component
GO:0046902Regulation of mitochondrial membrane permeabilityIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31163016980.59954032900.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2268851696
GSE13712_SHEARDown-0.0471028912
GSE13712_STATICUp0.0988744968
GSE19018Down-0.5612943130
GSE19899_A1Up0.1068389507
GSE19899_A2Up0.0652973102
PubMed_21979375_A1Up0.1489401444
PubMed_21979375_A2Up0.2186910364
GSE35957Down-0.4379930007
GSE36640Down-0.1116213431
GSE54402Up0.0115268589
GSE9593Down-0.0053793238
GSE43922Down-0.0427790316
GSE24585Up0.3874072714
GSE37065Up0.1572566683
GSE28863_A1Up0.2976869990
GSE28863_A2Up0.5045882543
GSE28863_A3Down-0.3750192612
GSE28863_A4Up0.0859537913
GSE48662Down-0.0842905473

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022857Proteomics;MicroarrayNon-Functional MTI (Weak)18668037
hsa-miR-874-3pMIMAT0004911MIRT037760CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040114CLASHFunctional MTI (Weak)23622248
hsa-miR-345-5pMIMAT0000772MIRT042728CLASHFunctional MTI (Weak)23622248
hsa-miR-30a-5pMIMAT0000087MIRT049951CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051255CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

2870196Glial cell cultures derived from newborn and aged (18-month-old) mouse cerebral hemispheres and maintained up to cell passage 11 were characterized immunocytochemically by using glial fibrillary acidic protein (GFA), and biochemically by using glutamine synthetase (GS), for astrocytes, and 2',3' cyclic nucleotide 3' phosphohydrolase (CNP) for oligodendrocytes
2870196GS and CNP activities did not significantly change with cell passage in cultures from newborn mouse
2870196In cultures derived from aged mouse, CNP activity did not change significantly whereas GS activity increased severalfold
Entries Per Page
Displaying Page of