HCSGD entry for CCR5

1. General information

Official gene symbolCCR5
Entrez ID1234
Gene full namechemokine (C-C motif) receptor 5 (gene/pseudogene)
Other gene symbolsCC-CKR-5 CCCKR5 CCR-5 CD195 CKR-5 CKR5 CMKBR5 IDDM22
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeIEPbiological_process
GO:0002407Dendritic cell chemotaxisTASbiological_process
GO:0003779Actin bindingIDAmolecular_function
GO:0004435Phosphatidylinositol phospholipase C activityTASmolecular_function
GO:0004950Chemokine receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmTAScellular_component
GO:0005768EndosomeIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006816Calcium ion transportIDAbiological_process
GO:0006935ChemotaxisTASbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0006968Cellular defense responseTASbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIMPbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationTASbiological_process
GO:0007267Cell-cell signalingIDAbiological_process
GO:0009897External side of plasma membraneIDAcellular_component
GO:0009986Cell surfaceIDAcellular_component
GO:0014808Release of sequestered calcium ion into cytosol by sarcoplasmic reticulumIDAbiological_process
GO:0015026Coreceptor activityTASmolecular_function
GO:0016032Viral processTASbiological_process
GO:0016493C-C chemokine receptor activityIDA NASmolecular_function
GO:0019221Cytokine-mediated signaling pathwayIDA NAS TASbiological_process
GO:0019722Calcium-mediated signalingIDAbiological_process
GO:0019957C-C chemokine bindingIPImolecular_function
GO:0023052SignalingIEPbiological_process
GO:0030260Entry into host cellTASbiological_process
GO:0070098Chemokine-mediated signaling pathwayIDA NAS TASbiological_process
GO:0070723Response to cholesterolIMPbiological_process
GO:0071222Cellular response to lipopolysaccharideIEPbiological_process
GO:0071791Chemokine (C-C motif) ligand 5 bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.34094743360.94674972460.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0366230038
GSE13712_SHEARDown-0.1298956610
GSE13712_STATICDown-0.0617427336
GSE19018Up0.1656040972
GSE19899_A1Up0.2773905044
GSE19899_A2Up0.3745206843
PubMed_21979375_A1Down-0.1289829424
PubMed_21979375_A2Down-0.0693289582
GSE35957Up0.1513650430
GSE36640Up0.0400372316
GSE54402Up0.2099349653
GSE9593Up0.0259938070
GSE43922Up0.0115638150
GSE24585Up0.1588314958
GSE37065Up0.0505585736
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.0445279756

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MaravirocDB04835 -
INCB9471DB05062 -
AMD-070DB05501 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23435301CCR5 was more highly expressed in CD4+ (16
22948867The potential effect of blocking the CCR5 receptor on HIV disease progression biomarkers is not well understood
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