| 21736542 | Jun dimerization protein 2 in oxygen restriction; control of senescence |
| 21736542 | Transcription factor Jun dimerization protein 2 (JDP2) which binds directly to histones and DNA, inhibits the acetylation and methylation of core histones and of reconstituted nucleosomes that contain JDP2-recognition DNA sequences |
| 21736542 | Oxygen induces the expression of the JDP2 gene and JDP2 then inhibits the recruitment of polycomb repressive complexes (PRCs1 and 2) to the promoter of the gene encoding p16(Ink4a), resulting in the inhibition of methylation of lysine 27 of histone H3 |
| 21736542 | These findings suggest that chromatin-remodeling factors, including the PRC complex controlled by JDP2, are important players in the senescence |
| 21197464 | Jun dimerization protein 2 controls senescence and differentiation via regulating histone modification |
| 21197464 | Transcription factor, Jun dimerization protein 2 (JDP2), binds directly to histones and DNAs and then inhibits the p300-mediated acetylation both of core histones and of reconstituted nucleosomes that contain JDP2 recognition DNA sequences |
| 21197464 | JDP2 plays a key role as a repressor of adipocyte differentiation by regulation of the expression of the gene C/EBPdelta via inhibition of histone acetylation |
| 21197464 | Moreover, JDP2-deficient mouse embryonic fibroblasts (JDP2(-/-) MEFs) are resistant to replicative senescence |
| 21197464 | JDP2 inhibits the recruitment of polycomb repressive complexes (PRC1 and PRC2) to the promoter of the gene encoding p16(Ink4a), resulting from the inhibition of methylation of lysine 27 of histone H3 (H3K27) |
| 21197464 | Therefore, it seems that chromatin-remodeling factors, including the PRC complex controlled by JDP2, may be important players in the senescence program |
| 21197464 | The novel mechanisms that underline the action of JDP2 in inducing cellular senescence and suppressing adipocyte differentiation are reviewed |
| 20950777 | Histone chaperone Jun dimerization protein 2 (JDP2): role in cellular senescence and aging |
| 20950777 | Transcription factor Jun dimerization protein 2 (JDP2) binds directly to histones and DNA, and inhibits p300-mediated acetylation of core histones and reconstituted nucleosomes that contain JDP2-recognition DNA sequences |
| 20950777 | The region of JDP2 that encompasses its histone-binding domain and DNA-binding region is essential to inhibit histone acetylation by histone acetyltransferases |
| 20950777 | Moreover, assays of nucleosome assembly in vitro demonstrate that JDP2 also has histone-chaperone activity |
| 20950777 | JDP2 inhibits recruitment of the polycomb repressive complexes 1 and 2 (PRC-1 and PRC-2) to the promoter of the gene that encodes p16(Ink4a) and inhibits the methylation of lysine 27 of histone H3 (H3K27) |
| 20950777 | Therefore, it seems that chromatin-remodeling factors that regulate association and dissociation of PRCs, and are controlled by JDP2, might play an important role in the senescence program |
| 25961985 | Here, we summarize the molecular mechanisms that mediate cellular aging and introduce the Jun dimerization protein 2 (JDP2) as a factor that regulates replicative senescence by mediating dissociation of PRCs from the p16Ink4a/Arf locus |
