HCSGD entry for SPPL3
1. General information
| Official gene symbol | SPPL3 |
|---|---|
| Entrez ID | 121665 |
| Gene full name | signal peptide peptidase like 3 |
| Other gene symbols | IMP2 MDHV1887 PRO4332 PSH1 PSL4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004190 | Aspartic-type endopeptidase activity | IEA | molecular_function |
| GO:0005791 | Rough endoplasmic reticulum | IDA | cellular_component |
| GO:0006509 | Membrane protein ectodomain proteolysis | IMP | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030660 | Golgi-associated vesicle membrane | IDA | cellular_component |
| GO:0042500 | Aspartic endopeptidase activity, intramembrane cleaving | IMP | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0071458 | Integral component of cytoplasmic side of endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0071556 | Integral component of lumenal side of endoplasmic reticulum membrane | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1495971848 | 0.9465215113 | 0.7740411834 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0932277248 |
| GSE13712_SHEAR | Down | -0.0378796266 |
| GSE13712_STATIC | Down | -0.1984426204 |
| GSE19018 | Up | 0.0207308955 |
| GSE19899_A1 | Up | 0.0012102406 |
| GSE19899_A2 | Up | 0.2056693202 |
| PubMed_21979375_A1 | Up | 0.4033060616 |
| PubMed_21979375_A2 | Up | 0.3866856604 |
| GSE35957 | Down | -0.0527723221 |
| GSE36640 | Up | 0.0132100442 |
| GSE54402 | Down | -0.0711212250 |
| GSE9593 | Up | 0.2480268167 |
| GSE43922 | Up | 0.1082999645 |
| GSE24585 | Up | 0.3487625752 |
| GSE37065 | Down | -0.0638376831 |
| GSE28863_A1 | Up | 0.6645932917 |
| GSE28863_A2 | Up | 0.5535748924 |
| GSE28863_A3 | Down | -0.1239141111 |
| GSE28863_A4 | Down | -0.0010847189 |
| GSE48662 | Up | 0.0611440382 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
