HCSGD entry for CLTC
1. General information
| Official gene symbol | CLTC |
|---|---|
| Entrez ID | 1213 |
| Gene full name | clathrin, heavy chain (Hc) |
| Other gene symbols | CHC CHC17 CLH-17 CLTCL2 Hc |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003725 | Double-stranded RNA binding | IDA | molecular_function |
| GO:0005198 | Structural molecule activity | IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005819 | Spindle | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006886 | Intracellular protein transport | IEA NAS | biological_process |
| GO:0006892 | Post-Golgi vesicle-mediated transport | TAS | biological_process |
| GO:0006898 | Receptor-mediated endocytosis | IMP | biological_process |
| GO:0007067 | Mitosis | IMP | biological_process |
| GO:0016192 | Vesicle-mediated transport | IEA | biological_process |
| GO:0019886 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | biological_process |
| GO:0030118 | Clathrin coat | NAS | cellular_component |
| GO:0030130 | Clathrin coat of trans-Golgi network vesicle | IEA | cellular_component |
| GO:0030132 | Clathrin coat of coated pit | IEA | cellular_component |
| GO:0030136 | Clathrin-coated vesicle | IDA | cellular_component |
| GO:0030669 | Clathrin-coated endocytic vesicle membrane | TAS | cellular_component |
| GO:0031623 | Receptor internalization | IMP | biological_process |
| GO:0032051 | Clathrin light chain binding | IPI | molecular_function |
| GO:0032588 | Trans-Golgi network membrane | TAS | cellular_component |
| GO:0033572 | Transferrin transport | IMP | biological_process |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
| GO:0071439 | Clathrin complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4599324266 | 0.8139126287 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0133397561 |
| GSE13712_SHEAR | Up | 0.1024462715 |
| GSE13712_STATIC | Up | 0.0345153349 |
| GSE19018 | Up | 0.0118974116 |
| GSE19899_A1 | Up | 0.0280951586 |
| GSE19899_A2 | Down | -0.1393498899 |
| PubMed_21979375_A1 | Down | -0.1025532677 |
| PubMed_21979375_A2 | Up | 0.0976159042 |
| GSE35957 | Up | 0.0941206377 |
| GSE36640 | Down | -0.1272659377 |
| GSE54402 | Up | 0.2101159137 |
| GSE9593 | Up | 0.1233985011 |
| GSE43922 | Up | 0.0081031512 |
| GSE24585 | Up | 0.4298981986 |
| GSE37065 | Down | -0.1104122557 |
| GSE28863_A1 | Up | 0.1300922944 |
| GSE28863_A2 | Up | 0.4505980048 |
| GSE28863_A3 | Down | -0.5443796591 |
| GSE28863_A4 | Up | 0.1155829335 |
| GSE48662 | Down | -0.1190843481 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020878 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023919 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-99a-3p | MIMAT0004511 | MIRT038715 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040142 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT041098 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041695 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044262 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049256 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051201 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051640 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-4326 | MIMAT0016888 | MIRT052842 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
