HCSGD entry for LRRK2

1. General information

Official gene symbolLRRK2
Entrez ID120892
Gene full nameleucine-rich repeat kinase 2
Other gene symbolsAURA17 DARDARIN PARK8 RIPK7 ROCO2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeIDAbiological_process
GO:0000186Activation of MAPKK activityIDAbiological_process
GO:0000187Activation of MAPK activityIDAbiological_process
GO:0001934Positive regulation of protein phosphorylationIMPbiological_process
GO:0003924GTPase activityIDAmolecular_function
GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0004708MAP kinase kinase activityIDAmolecular_function
GO:0005096GTPase activator activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005525GTP bindingIDAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005802Trans-Golgi networkIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006184GTP catabolic processIDAbiological_process
GO:0006914AutophagyIEAbiological_process
GO:0006979Response to oxidative stressIMPbiological_process
GO:0007264Small GTPase mediated signal transductionIEAbiological_process
GO:0007406Negative regulation of neuroblast proliferationIMPbiological_process
GO:0007528Neuromuscular junction developmentIMPbiological_process
GO:0008021Synaptic vesicleIEAcellular_component
GO:0008340Determination of adult lifespanIMPbiological_process
GO:0010508Positive regulation of autophagyIMP ISSbiological_process
GO:0010942Positive regulation of cell deathIMPbiological_process
GO:0014043Negative regulation of neuron maturationIMPbiological_process
GO:0015631Tubulin bindingIDAmolecular_function
GO:0017048Rho GTPase bindingIPImolecular_function
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0018107Peptidyl-threonine phosphorylationIDAbiological_process
GO:0021772Olfactory bulb developmentIMPbiological_process
GO:0022028Tangential migration from the subventricular zone to the olfactory bulbIMPbiological_process
GO:0030424AxonIEAcellular_component
GO:0031398Positive regulation of protein ubiquitinationIDAbiological_process
GO:0032436Positive regulation of proteasomal ubiquitin-dependent protein catabolic processISSbiological_process
GO:0032473Cytoplasmic side of mitochondrial outer membraneIDAcellular_component
GO:0032839Dendrite cytoplasmIDAcellular_component
GO:0034211GTP-dependent protein kinase activityIDA IMPmolecular_function
GO:0034260Negative regulation of GTPase activityIDAbiological_process
GO:0035564Regulation of kidney sizeISSbiological_process
GO:0035640Exploration behaviorIMPbiological_process
GO:0040012Regulation of locomotionIMPbiological_process
GO:0042391Regulation of membrane potentialIMPbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043005Neuron projectionIDAcellular_component
GO:0043025Neuronal cell bodyIDAcellular_component
GO:0043068Positive regulation of programmed cell deathIDAbiological_process
GO:0043547Positive regulation of GTPase activityIDAbiological_process
GO:0044325Ion channel bindingIPImolecular_function
GO:0045121Membrane raftIEAcellular_component
GO:0046777Protein autophosphorylationIDA IMPbiological_process
GO:0048312Intracellular distribution of mitochondriaIMPbiological_process
GO:0060161Positive regulation of dopamine receptor signaling pathwayIMPbiological_process
GO:0061002Negative regulation of dendritic spine morphogenesisIMPbiological_process
GO:0070997Neuron deathIMPbiological_process
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
GO:2000173Negative regulation of branching morphogenesis of a nerveIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07009431250.45918853390.56610456361.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1116631525
GSE13712_SHEARUp0.0224487422
GSE13712_STATICDown-0.1309083734
GSE19018Down-0.1998682487
GSE19899_A1Down-0.0343151599
GSE19899_A2Down-0.3505114758
PubMed_21979375_A1Up0.2631346094
PubMed_21979375_A2Up0.1794639942
GSE35957Up0.1908028760
GSE36640Down-0.0659340615
GSE54402Down-0.4840315570
GSE9593Down-0.0918236867
GSE43922Up0.2984065260
GSE24585Up0.2289537542
GSE37065Up0.4736662920
GSE28863_A1Up1.1800595212
GSE28863_A2Up1.5519909959
GSE28863_A3Down-0.3966217786
GSE28863_A4Up0.0184931104
GSE48662Down-0.0329444375

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-205-5pMIMAT0000266MIRT007191Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23125283
hsa-miR-335-5pMIMAT0000765MIRT017071MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.