HCSGD entry for TPP1

1. General information

Official gene symbolTPP1
Entrez ID1200
Gene full nametripeptidyl peptidase I
Other gene symbolsCLN2 LPIC TPP-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004175Endopeptidase activityIDA IMPmolecular_function
GO:0004252Serine-type endopeptidase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005764LysosomeIDA IMPcellular_component
GO:0006508ProteolysisIMPbiological_process
GO:0006629Lipid metabolic processTASbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0007040Lysosome organizationIEA ISSbiological_process
GO:0007399Nervous system developmentIMPbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0008233Peptidase activityIMPmolecular_function
GO:0008236Serine-type peptidase activityIEA IMPmolecular_function
GO:0008240Tripeptidyl-peptidase activityIDA IMPmolecular_function
GO:0030163Protein catabolic processNASbiological_process
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0042277Peptide bindingISSmolecular_function
GO:0042470MelanosomeIEAcellular_component
GO:0043171Peptide catabolic processIMPbiological_process
GO:0043202Lysosomal lumenTAScellular_component
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045453Bone resorptionIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050885Neuromuscular process controlling balanceIEA ISSbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00478074160.98753215680.18217532471.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4126808152
GSE13712_SHEARUp0.0856559446
GSE13712_STATICDown-0.0604818825
GSE19018Up0.0230669164
GSE19899_A1Up0.1905794103
GSE19899_A2Up0.6216814846
PubMed_21979375_A1Up0.6670333294
PubMed_21979375_A2Up1.0112939431
GSE35957Down-0.2630970945
GSE36640Up1.3510334315
GSE54402Up0.3141223029
GSE9593Up1.0328039355
GSE43922Up0.0776150756
GSE24585Up0.4032478401
GSE37065Up0.3816707912
GSE28863_A1Up0.0983982066
GSE28863_A2Up1.1220386628
GSE28863_A3Down-0.2397705485
GSE28863_A4Down-0.1481266921
GSE48662Up0.8017457324

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022359MicroarrayFunctional MTI (Weak)18668037
hsa-miR-877-5pMIMAT0004949MIRT037364CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24917814SIRT1 positively regulated the expression of tripeptidyl peptidase 1 (TPP1), a component of the shelterin pathway that protects chromosome ends from DNA damage
24917814Together, the results demonstrate that SIRT1 quenches age-related MSCs senescence by mechanisms that include enhanced TPP1 expression, increased telomerase activity and reduced DNA damage
Entries Per Page
Displaying Page of