HCSGD entry for CLCN2

1. General information

Official gene symbolCLCN2
Entrez ID1181
Gene full namechloride channel, voltage-sensitive 2
Other gene symbolsCIC-2 CLC2 ECA2 ECA3 EGI11 EGI3 EGMA EJM6 EJM8 clC-2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005247Voltage-gated chloride channel activityIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0030554Adenyl nucleotide bindingIEAmolecular_function
GO:0034220Ion transmembrane transportTASbiological_process
GO:0034707Chloride channel complexIEAcellular_component
GO:0044070Regulation of anion transportTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060041Retina development in camera-type eyeIEAbiological_process
GO:0060689Cell differentiation involved in salivary gland developmentIEAbiological_process
GO:1902476Chloride transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.21479462030.95844179170.89272212221.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0979461665
GSE13712_SHEARDown-0.1290193477
GSE13712_STATICDown-0.1605966668
GSE19018Up0.1648137421
GSE19899_A1Up0.0679422051
GSE19899_A2Up0.2678319012
PubMed_21979375_A1Up0.1443817910
PubMed_21979375_A2Up0.5305586649
GSE35957Up0.0873192575
GSE36640Up0.1708524044
GSE54402Up0.1440760934
GSE9593Up0.1694445405
GSE43922Up0.2677475240
GSE24585Down-0.0705947253
GSE37065Up0.0288090460
GSE28863_A1Up0.0047122494
GSE28863_A2Up0.2736499176
GSE28863_A3Up0.1444156156
GSE28863_A4Up0.0043824950
GSE48662Down-0.1215030144

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

LubiprostoneDB01046 APRD01298

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017077MicroarrayFunctional MTI (Weak)18185580
hsa-miR-1260bMIMAT0015041MIRT052784CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.