HCSGD entry for ADCYAP1R1

1. General information

Official gene symbol	ADCYAP1R1
Entrez ID	117
Gene full name	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Other gene symbols	PAC1 PAC1R PACAPR PACAPRI
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0004872	Receptor activity	TAS	molecular_function
GO:0004930	G-protein coupled receptor activity	IEA	molecular_function
GO:0004999	Vasoactive intestinal polypeptide receptor activity	IEA	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005768	Endosome	IEA	cellular_component
GO:0005791	Rough endoplasmic reticulum	IEA	cellular_component
GO:0005886	Plasma membrane	IEA TAS	cellular_component
GO:0005887	Integral component of plasma membrane	TAS	cellular_component
GO:0005901	Caveola	IEA	cellular_component
GO:0005923	Tight junction	IEA	cellular_component
GO:0007166	Cell surface receptor signaling pathway	TAS	biological_process
GO:0007169	Transmembrane receptor protein tyrosine kinase signaling pathway	TAS	biological_process
GO:0007190	Activation of adenylate cyclase activity	TAS	biological_process
GO:0007202	Activation of phospholipase C activity	IEA	biological_process
GO:0007283	Spermatogenesis	IEA	biological_process
GO:0008179	Adenylate cyclase binding	IEA	molecular_function
GO:0009986	Cell surface	IEA	cellular_component
GO:0010524	Positive regulation of calcium ion transport into cytosol	IEA	biological_process
GO:0016021	Integral component of membrane	IEA	cellular_component
GO:0019933	CAMP-mediated signaling	IEA	biological_process
GO:0030154	Cell differentiation	IEA	biological_process
GO:0030306	ADP-ribosylation factor binding	IEA	molecular_function
GO:0030819	Positive regulation of cAMP biosynthetic process	IEA	biological_process
GO:0032355	Response to estradiol	IEA	biological_process
GO:0033555	Multicellular organismal response to stress	IEA	biological_process
GO:0042493	Response to drug	IEA	biological_process
GO:0042923	Neuropeptide binding	IEA	molecular_function
GO:0043005	Neuron projection	IEA	cellular_component
GO:0043235	Receptor complex	IDA	cellular_component
GO:0045471	Response to ethanol	IEA	biological_process
GO:0046545	Development of primary female sexual characteristics	IEA	biological_process
GO:0048011	Neurotrophin TRK receptor signaling pathway	TAS	biological_process
GO:0060548	Negative regulation of cell death	IEA	biological_process
GO:0060732	Positive regulation of inositol phosphate biosynthetic process	IEA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.5161035219	0.8683060560	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.1597635938
GSE13712_SHEAR	Up	0.0095433555
GSE13712_STATIC	Up	0.0454877460
GSE19018	Down	-0.0000881776
GSE19899_A1	Up	0.0973929472
GSE19899_A2	Up	0.0824159203
PubMed_21979375_A1	Up	0.0097069468
PubMed_21979375_A2	Down	-0.2465974698
GSE35957	Up	0.0915939598
GSE36640	Down	-0.0476555972
GSE54402	Up	0.3528212637
GSE9593	Down	-0.0842615978
GSE43922	Up	0.0652146515
GSE24585	Up	0.1556777255
GSE37065	Up	0.0228315495
GSE28863_A1	Down	-0.1197733103
GSE28863_A2	Up	0.3006539425
GSE28863_A3	Up	0.3148436478
GSE28863_A4	Up	0.0034053872
GSE48662	Up	0.0792881893

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results