HCSGD entry for ARAP1

1. General information

Official gene symbolARAP1
Entrez ID116985
Gene full nameArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Other gene symbolsCENTD2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001921Positive regulation of receptor recyclingIEAbiological_process
GO:0005096GTPase activator activityIEAmolecular_function
GO:0005100Rho GTPase activator activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005547Phosphatidylinositol-3,4,5-trisphosphate bindingIDAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005802Trans-Golgi networkIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0007165Signal transductionIEAbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0008060ARF GTPase activator activityIDA IEAmolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008360Regulation of cell shapeIMPbiological_process
GO:0030037Actin filament reorganization involved in cell cycleTASbiological_process
GO:0031410Cytoplasmic vesicleIEAcellular_component
GO:0031702Type 1 angiotensin receptor bindingIEAmolecular_function
GO:0032312Regulation of ARF GTPase activityIEAbiological_process
GO:0032580Golgi cisterna membraneIEAcellular_component
GO:0043089Positive regulation of Cdc42 GTPase activityIDAbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0051270Regulation of cellular component movementIMPbiological_process
GO:0051491Positive regulation of filopodium assemblyIMPbiological_process
GO:0051497Negative regulation of stress fiber assemblyIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15478424830.88127145630.78221161231.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0376897677
GSE13712_SHEARDown-0.2998428345
GSE13712_STATICDown-0.0155891338
GSE19018Up0.0286239260
GSE19899_A1Down-0.0843816801
GSE19899_A2Down-0.0355640096
PubMed_21979375_A1Up0.3192665139
PubMed_21979375_A2Up0.3663524128
GSE35957Down-0.1634119931
GSE36640Down-0.0449407435
GSE54402Up0.2342882108
GSE9593Down-0.0130480902
GSE43922Up0.0589323140
GSE24585Up0.0581238227
GSE37065Up0.0615565928
GSE28863_A1Up0.6866089322
GSE28863_A2Up0.5515362431
GSE28863_A3Down-0.1805554338
GSE28863_A4Down-0.0311252476
GSE48662Up1.0126225396

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-18a-3pMIMAT0002891MIRT040872CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042346CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.