HCSGD entry for CKS1B
1. General information
| Official gene symbol | CKS1B |
|---|---|
| Entrez ID | 1163 |
| Gene full name | CDC28 protein kinase regulatory subunit 1B |
| Other gene symbols | CKS1 PNAS-16 PNAS-18 ckshs1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0016538 | Cyclin-dependent protein serine/threonine kinase regulator activity | IEA | molecular_function |
| GO:0051301 | Cell division | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9920764675 | 0.0003816002 | 0.9999902473 | 0.0361298561 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.1907282465 |
| GSE13712_SHEAR | Down | -0.0658602792 |
| GSE13712_STATIC | Down | -0.4483428208 |
| GSE19018 | Up | 0.2608364987 |
| GSE19899_A1 | Down | -1.5411163600 |
| GSE19899_A2 | Down | -2.1221699847 |
| PubMed_21979375_A1 | Down | -0.9081674853 |
| PubMed_21979375_A2 | Down | -2.6373141541 |
| GSE35957 | Down | -1.8827373847 |
| GSE36640 | Down | -2.9277852597 |
| GSE54402 | Down | -0.4179777047 |
| GSE9593 | Down | -0.7620011549 |
| GSE43922 | Down | -0.5014233273 |
| GSE24585 | Down | -0.0777994059 |
| GSE37065 | Up | 0.1222497762 |
| GSE28863_A1 | Down | -0.4353427513 |
| GSE28863_A2 | Down | -0.0962573441 |
| GSE28863_A3 | Down | -0.1233088793 |
| GSE28863_A4 | Down | -0.0029857135 |
| GSE48662 | Down | -0.4594236219 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Meta Vanadate | DB02681 | EXPT03214 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-941 | MIMAT0004984 | MIRT036562 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-425-5p | MIMAT0003393 | MIRT039329 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048080 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15610763 | Other genes, such as Cdc28 protein kinase 1 (Cks1b), v-myb myeloblastosis viral oncogene homolog (MybL2), pyruvate kinase, muscle 2 (Pkm2) and Forkhead box M1 (FoxM1), were down-regulated only upon TGF-beta1 treatment but not by cellular senescence |
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