HCSGD entry for UHRF2
1. General information
| Official gene symbol | UHRF2 |
|---|---|
| Entrez ID | 115426 |
| Gene full name | ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase |
| Other gene symbols | NIRF RNF107 URF2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005720 | Nuclear heterochromatin | ISS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008283 | Cell proliferation | IEP | biological_process |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0030154 | Cell differentiation | IEP | biological_process |
| GO:0042393 | Histone binding | ISS | molecular_function |
| GO:0051726 | Regulation of cell cycle | TAS | biological_process |
| GO:0051865 | Protein autoubiquitination | IDA | biological_process |
| GO:0071158 | Positive regulation of cell cycle arrest | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5726286653 | 0.2849837012 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1159876874 |
| GSE13712_SHEAR | Down | -0.2883394058 |
| GSE13712_STATIC | Down | -0.3897688532 |
| GSE19018 | Up | 0.2818242560 |
| GSE19899_A1 | Up | 0.2561840867 |
| GSE19899_A2 | Down | -0.6520649153 |
| PubMed_21979375_A1 | Down | -0.1859197791 |
| PubMed_21979375_A2 | Down | -0.1707121562 |
| GSE35957 | Down | -0.2160806558 |
| GSE36640 | Down | -0.7928072115 |
| GSE54402 | Up | 0.2764334248 |
| GSE9593 | Up | 0.2181444826 |
| GSE43922 | Down | -0.0769562740 |
| GSE24585 | Up | 0.0991797280 |
| GSE37065 | Up | 0.2071528014 |
| GSE28863_A1 | Down | -0.0311940139 |
| GSE28863_A2 | Down | -0.0113082852 |
| GSE28863_A3 | Up | 0.0019214248 |
| GSE28863_A4 | Up | 0.1252450298 |
| GSE48662 | Down | -0.0184599247 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7a-5p | MIMAT0000062 | MIRT004321 | qRT-PCR//Western blot//Luciferase reporter assay | Functional MTI | 19818775 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018641 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028675 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046615 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-let-7a-5p | MIMAT0000062 | NA | hsa-let-7a | {Western blot} | {overexpression by miRNA mimics tranfection} | 22018986 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
