HCSGD entry for CYGB
1. General information
| Official gene symbol | CYGB |
|---|---|
| Entrez ID | 114757 |
| Gene full name | cytoglobin |
| Other gene symbols | HGB STAP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004601 | Peroxidase activity | IEA ISS | molecular_function |
| GO:0005344 | Oxygen transporter activity | IEA NAS | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006979 | Response to oxidative stress | IEA ISS | biological_process |
| GO:0008152 | Metabolic process | ISS | biological_process |
| GO:0015671 | Oxygen transport | NAS | biological_process |
| GO:0019825 | Oxygen binding | IEA | molecular_function |
| GO:0020037 | Heme binding | IEA | molecular_function |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0055114 | Oxidation-reduction process | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0054345086 | 0.9168817446 | 0.1940864315 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1152345610 |
| GSE13712_SHEAR | Down | -0.0647756781 |
| GSE13712_STATIC | Down | -0.0496485167 |
| GSE19018 | Up | 0.2416261277 |
| GSE19899_A1 | Up | 0.3420147116 |
| GSE19899_A2 | Up | 1.2848097998 |
| PubMed_21979375_A1 | Up | 0.7371612727 |
| PubMed_21979375_A2 | Up | 1.4394577216 |
| GSE35957 | Down | -0.6342034823 |
| GSE36640 | Down | -0.3809881226 |
| GSE54402 | Up | 0.4681954255 |
| GSE9593 | Up | 0.6118792586 |
| GSE43922 | Up | 1.0949451621 |
| GSE24585 | Up | 0.0350318292 |
| GSE37065 | Up | 0.7175532557 |
| GSE28863_A1 | Down | -0.4696972822 |
| GSE28863_A2 | Up | 0.2144511567 |
| GSE28863_A3 | Up | 0.1629617454 |
| GSE28863_A4 | Down | -0.0120724994 |
| GSE48662 | Up | 1.2351124514 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016773 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27146058 | Absence of cytoglobin promotes multiple organ abnormalities in aged mice |
| 27146058 | Cytoglobin (Cygb) was identified in hepatic stellate cells (HSCs) and pericytes of all organs; however, the effects of Cygb on cellular functions remain unclear |
| 27146058 | Here, we report spontaneous and age-dependent malformations in multiple organs of Cygb(-/-) mice |
| 27146058 | Twenty-six percent of young Cygb(-/-) mice (<1 year old) showed heart hypertrophy, cystic disease in the kidney or ovary, loss of balance, liver fibrosis and lymphoma |
| 27146058 | 3% (82/115) of aged Cygb(-/-) mice (1-2 years old) exhibited abnormalities, such as heart hypertrophy and cancer development in multiple organs; by contrast, 5 |
| 27146058 | Interestingly, serum and urine analysis demonstrated that the concentration of nitric oxide metabolites increased significantly in Cygb(-/-) mice, resulting in an imbalance in the oxidative stress and antioxidant defence system that was reversed by N(G)-monomethyl-L-arginine treatment |
| 27146058 | A senescent phenotype and evidence of DNA damage were found in primary HSCs and the liver of aged Cygb(-/-) mice |
| 27146058 | Thus, the absence of Cygb in pericytes provokes organ abnormalities, possibly via derangement of the nitric oxide and antioxidant defence system and through accelerated cellular senescence |
| 10698358 | The mean +/- SD AChE per gram hemoglobin (U/g Hgb) activities in whole blood (WB), purified human red blood cells (PRBCs), young human red blood cells (y-RBCs), mid age human red blood cells (m-RBCs) and old human red blood cells (o-RBCs) in CRF-patients were 31 |
| 9698047 | The mean +/- 1 SD AChE per gram hemoglobin (U/g Hgb) activities in whole blood (WB) purified human red blood cells (PRBCs), young human red blood cells (y-RBCs), mid age human red blood cells (m-RBCs) and old human red blood cells (o-RBCs) were 27 |
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