HCSGD entry for CHUK
1. General information
| Official gene symbol | CHUK |
|---|---|
| Entrez ID | 1147 |
| Gene full name | conserved helix-loop-helix ubiquitous kinase |
| Other gene symbols | IKBKA IKK-alpha IKK1 IKKA NFKBIKA TCF16 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002011 | Morphogenesis of an epithelial sheet | IEA | biological_process |
| GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0003009 | Skeletal muscle contraction | IEA | biological_process |
| GO:0004672 | Protein kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006954 | Inflammatory response | TAS | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007249 | I-kappaB kinase/NF-kappaB signaling | TAS | biological_process |
| GO:0007252 | I-kappaB phosphorylation | TAS | biological_process |
| GO:0007266 | Rho protein signal transduction | IEA | biological_process |
| GO:0007595 | Lactation | IEA | biological_process |
| GO:0008384 | IkappaB kinase activity | TAS | molecular_function |
| GO:0008385 | IkappaB kinase complex | TAS | cellular_component |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0009615 | Response to virus | TAS | biological_process |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0009653 | Anatomical structure morphogenesis | TAS | biological_process |
| GO:0009898 | Cytoplasmic side of plasma membrane | ISS | cellular_component |
| GO:0030316 | Osteoclast differentiation | IEA | biological_process |
| GO:0032481 | Positive regulation of type I interferon production | TAS | biological_process |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0033194 | Response to hydroperoxide | IEA | biological_process |
| GO:0033598 | Mammary gland epithelial cell proliferation | IEA | biological_process |
| GO:0034134 | Toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0034138 | Toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0034142 | Toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0034146 | Toll-like receptor 5 signaling pathway | TAS | biological_process |
| GO:0034162 | Toll-like receptor 9 signaling pathway | TAS | biological_process |
| GO:0034166 | Toll-like receptor 10 signaling pathway | TAS | biological_process |
| GO:0035631 | CD40 receptor complex | ISS | cellular_component |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0035872 | Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | TAS | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0038123 | Toll-like receptor TLR1:TLR2 signaling pathway | TAS | biological_process |
| GO:0038124 | Toll-like receptor TLR6:TLR2 signaling pathway | TAS | biological_process |
| GO:0042475 | Odontogenesis of dentin-containing tooth | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | TAS | biological_process |
| GO:0043200 | Response to amino acid | IEA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IDA | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0050852 | T cell receptor signaling pathway | TAS | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | TAS | biological_process |
| GO:0051146 | Striated muscle cell differentiation | IEA | biological_process |
| GO:0060749 | Mammary gland alveolus development | IEA | biological_process |
| GO:0070423 | Nucleotide-binding oligomerization domain containing signaling pathway | TAS | biological_process |
| GO:0071356 | Cellular response to tumor necrosis factor | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2881510657 | 0.3053584362 | 0.9867843091 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2006495628 |
| GSE13712_SHEAR | Up | 0.2443968451 |
| GSE13712_STATIC | Up | 0.4026263645 |
| GSE19018 | Down | -0.7220645209 |
| GSE19899_A1 | Up | 0.1054246434 |
| GSE19899_A2 | Down | -0.2678085882 |
| PubMed_21979375_A1 | Up | 0.1404965706 |
| PubMed_21979375_A2 | Down | -0.0617141103 |
| GSE35957 | Up | 0.0589730650 |
| GSE36640 | Up | 0.1018916195 |
| GSE54402 | Up | 0.4712094167 |
| GSE9593 | Down | -0.3782365328 |
| GSE43922 | Up | 0.0106978552 |
| GSE24585 | Down | -0.3284575766 |
| GSE37065 | Up | 0.0847396677 |
| GSE28863_A1 | Up | 0.0730333604 |
| GSE28863_A2 | Up | 0.3642854042 |
| GSE28863_A3 | Down | -0.3716948137 |
| GSE28863_A4 | Up | 0.1416601125 |
| GSE48662 | Down | -0.1893056826 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Aminosalicylic Acid | DB00233 | APRD00749 | EXPT00693 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | MIRT005552 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20711193 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT005554 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20711193 |
| hsa-miR-223-3p | MIMAT0000280 | MIRT005555 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20711193 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT007041 | Luciferase reporter assay | Functional MTI | 22660635 |
| hsa-miR-195-5p | MIMAT0000461 | MIRT007169 | Luciferase reporter assay | Functional MTI | 23487264 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26618897 | Moreover, LiCl boosted 8-oxo-dG staining, expression of IKKalpha and MMP-10 |
| 22740410 | HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-kappaB and depends on chronically activated IKKalpha and p65/RelA |
| 22740410 | Consistent with a critical role of IKKalpha in the transcriptional activity of NF-kappaB, IKKalpha deficiency drastically decreased NF-kappaB trans-activation by Tax, although it only modestly reduced Tax-mediated I-kappaBalpha degradation and NF-kappaB nuclear localization |
| 22740410 | The senescence checkpoint triggered by Tax is driven by the transcriptional activity of NF-kappaB, which depends on activated IKKalpha and p65/RelA |
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