HCSGD entry for TIRAP

1. General information

Official gene symbolTIRAP
Entrez ID114609
Gene full nametoll-interleukin 1 receptor (TIR) domain containing adaptor protein
Other gene symbolsBACTS1 Mal MyD88-2 wyatt
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0005080Protein kinase C bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005546Phosphatidylinositol-4,5-bisphosphate bindingISSmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayISSbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingIEAbiological_process
GO:0030099Myeloid cell differentiationISSbiological_process
GO:0030139Endocytic vesicleISScellular_component
GO:0030674Protein binding, bridgingNASmolecular_function
GO:0030890Positive regulation of B cell proliferationISSbiological_process
GO:0032496Response to lipopolysaccharideIDAbiological_process
GO:0032587Ruffle membraneISScellular_component
GO:0032648Regulation of interferon-beta productionISSbiological_process
GO:0032735Positive regulation of interleukin-12 productionISSbiological_process
GO:0032738Positive regulation of interleukin-15 productionIDAbiological_process
GO:0032757Positive regulation of interleukin-8 productionIMPbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIMPbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034137Positive regulation of toll-like receptor 2 signaling pathwayIMPbiological_process
GO:0034141Positive regulation of toll-like receptor 3 signaling pathwayISSbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034145Positive regulation of toll-like receptor 4 signaling pathwayIMPbiological_process
GO:0035662Toll-like receptor 4 bindingIPImolecular_function
GO:0035663Toll-like receptor 2 bindingIPImolecular_function
GO:0035665TIRAP-dependent toll-like receptor 4 signaling pathwayIDAbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0044130Negative regulation of growth of symbiont in hostISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045088Regulation of innate immune responseICbiological_process
GO:0045410Positive regulation of interleukin-6 biosynthetic processIMPbiological_process
GO:0046330Positive regulation of JNK cascadeIMPbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0050830Defense response to Gram-positive bacteriumISSbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:00709353'-UTR-mediated mRNA stabilizationIDAbiological_process
GO:0071221Cellular response to bacterial lipopeptideISSbiological_process
GO:0071223Cellular response to lipoteichoic acidISSbiological_process
GO:0090023Positive regulation of neutrophil chemotaxisISSbiological_process
GO:0090073Positive regulation of protein homodimerization activityIDAbiological_process
GO:2000340Positive regulation of chemokine (C-X-C motif) ligand 1 productionISSbiological_process
GO:2000343Positive regulation of chemokine (C-X-C motif) ligand 2 productionISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.88018419510.46015509670.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0233705360
GSE13712_SHEARDown-0.0890359354
GSE13712_STATICUp0.0219624632
GSE19018Down-0.1172501138
GSE19899_A1Up0.0008419022
GSE19899_A2Up0.1491249094
PubMed_21979375_A1Down-0.1037316157
PubMed_21979375_A2Down-0.1578191834
GSE35957Down-0.1335426028
GSE36640Up0.0099520710
GSE54402Up0.2655221669
GSE9593Up0.0013545578
GSE43922Down-0.0807200293
GSE24585Up0.0689715989
GSE37065Up0.0679879156
GSE28863_A1Down-0.0663005558
GSE28863_A2Down-0.2191816393
GSE28863_A3Down-0.4208367606
GSE28863_A4Down-0.0568816547
GSE48662Up0.0789080782

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-145-5pMIMAT0000437MIRT004748Immunoprecipitaion//Western blot//CommunoprecipitaionFunctional MTI19898489
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.