HCSGD entry for CHRNB3

1. General information

Official gene symbolCHRNB3
Entrez ID1142
Gene full namecholinergic receptor, nicotinic, beta 3 (neuronal)
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004889Acetylcholine-activated cation-selective channel activityIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005892Acetylcholine-gated channel complexIEAcellular_component
GO:0006810TransportTASbiological_process
GO:0006812Cation transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007271Synaptic transmission, cholinergicTASbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0015267Channel activityTASmolecular_function
GO:0016021Integral component of membraneNAScellular_component
GO:0030054Cell junctionIEAcellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0042166Acetylcholine bindingIEAmolecular_function
GO:0043005Neuron projectionIEAcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0055085Transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.49319497740.92322767370.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0677965590
GSE13712_SHEARDown-0.0475276341
GSE13712_STATICUp0.0787724378
GSE19018Up0.0828870378
GSE19899_A1Up0.1965371446
GSE19899_A2Up0.2181640562
PubMed_21979375_A1Up0.0669849695
PubMed_21979375_A2Up0.0580269096
GSE35957Up0.0095136405
GSE36640Up0.0666888661
GSE54402Down-0.0447462357
GSE9593Down-0.1162467113
GSE43922Up0.0216926083
GSE24585Up0.1432882148
GSE37065Up0.0233656579
GSE28863_A1Down-0.0694758069
GSE28863_A2Up0.2079606085
GSE28863_A3Up0.3419951570
GSE28863_A4Down-0.0564227433
GSE48662Down-0.1592258331

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NicotineDB00184 APRD00200 | EXPT02315 | DB09463
GalantamineDB00674 APRD00206 | EXPT01628

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.