HCSGD entry for CHRNB1

1. General information

Official gene symbolCHRNB1
Entrez ID1140
Gene full namecholinergic receptor, nicotinic, beta 1 (muscle)
Other gene symbolsACHRB CHRNB CMS1D CMS2A SCCMS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001941Postsynaptic membrane organizationIMPbiological_process
GO:0004889Acetylcholine-activated cation-selective channel activityIEA ISSmolecular_function
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0005892Acetylcholine-gated channel complexIEA IMPcellular_component
GO:0006812Cation transportIMPbiological_process
GO:0006936Muscle contractionIMPbiological_process
GO:0007165Signal transductionIMPbiological_process
GO:0007271Synaptic transmission, cholinergicIMPbiological_process
GO:0007274Neuromuscular synaptic transmissionIMPbiological_process
GO:0015267Channel activityIMPmolecular_function
GO:0015276Ligand-gated ion channel activityISSmolecular_function
GO:0015464Acetylcholine receptor activityIMPmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0030054Cell junctionIEAcellular_component
GO:0034220Ion transmembrane transportISSbiological_process
GO:0035095Behavioral response to nicotineIMPbiological_process
GO:0042166Acetylcholine bindingIEA ISSmolecular_function
GO:0042391Regulation of membrane potentialIEA ISSbiological_process
GO:0045202SynapseIMPcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0048747Muscle fiber developmentIMPbiological_process
GO:0050877Neurological system processIMPbiological_process
GO:0055085Transmembrane transportIMP ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14993331940.74349188480.77456808641.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1953017627
GSE13712_SHEARUp0.1997979087
GSE13712_STATICDown-0.2009830059
GSE19018Up0.2043407193
GSE19899_A1Up0.0457009333
GSE19899_A2Down-0.5550385261
PubMed_21979375_A1Up0.5172193976
PubMed_21979375_A2Down-0.5036375072
GSE35957Down-0.0577701421
GSE36640Up0.3985856622
GSE54402Down-0.4148815713
GSE9593Up0.1894207043
GSE43922Up0.3876937952
GSE24585Up0.7549790549
GSE37065Down-0.0702607609
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.0944070193

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GalantamineDB00674 APRD00206 | EXPT01628

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-98-5pMIMAT0000096MIRT004951qRT-PCRFunctional MTI (Weak)17942906
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.