HCSGD entry for CHRNA5
1. General information
| Official gene symbol | CHRNA5 |
|---|---|
| Entrez ID | 1138 |
| Gene full name | cholinergic receptor, nicotinic, alpha 5 (neuronal) |
| Other gene symbols | LNCR2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004889 | Acetylcholine-activated cation-selective channel activity | IEA NAS TAS | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005892 | Acetylcholine-gated channel complex | IC | cellular_component |
| GO:0006810 | Transport | NAS | biological_process |
| GO:0006811 | Ion transport | IEA | biological_process |
| GO:0006812 | Cation transport | NAS TAS | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0015276 | Ligand-gated ion channel activity | TAS | molecular_function |
| GO:0015464 | Acetylcholine receptor activity | IDA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0034220 | Ion transmembrane transport | NAS TAS | biological_process |
| GO:0035095 | Behavioral response to nicotine | IMP | biological_process |
| GO:0045211 | Postsynaptic membrane | IEA | cellular_component |
| GO:0055085 | Transmembrane transport | NAS TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8814896622 | 0.0250346377 | 0.9999902473 | 0.3048180222 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0006332710 |
| GSE13712_SHEAR | Up | 0.5227094582 |
| GSE13712_STATIC | Up | 0.5040744170 |
| GSE19018 | Down | -0.0109176481 |
| GSE19899_A1 | Down | -0.0206719306 |
| GSE19899_A2 | Down | -1.3350700665 |
| PubMed_21979375_A1 | Down | -0.1249387889 |
| PubMed_21979375_A2 | Down | -0.5310514800 |
| GSE35957 | Up | 0.1999549673 |
| GSE36640 | Down | -1.1841921254 |
| GSE54402 | Down | -0.0048539148 |
| GSE9593 | Down | -0.2361394589 |
| GSE43922 | Down | -0.7571819591 |
| GSE24585 | Up | 0.2319027468 |
| GSE37065 | Up | 0.1056780129 |
| GSE28863_A1 | Down | -0.4820004570 |
| GSE28863_A2 | Down | -0.4938039078 |
| GSE28863_A3 | Down | -0.0846404602 |
| GSE28863_A4 | Down | -0.2000389099 |
| GSE48662 | Down | -0.1729983973 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Nicotine | DB00184 | APRD00200 | EXPT02315 | DB09463 |
| Galantamine | DB00674 | APRD00206 | EXPT01628 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-132-3p | MIMAT0000426 | MIRT021766 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039616 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047593 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
