HCSGD entry for ADC
1. General information
| Official gene symbol | ADC |
|---|---|
| Entrez ID | 113451 |
| Gene full name | arginine decarboxylase |
| Other gene symbols | AZI2 ODC-p ODC1L |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006591 | Ornithine metabolic process | IEA | biological_process |
| GO:0006595 | Polyamine metabolic process | TAS | biological_process |
| GO:0006596 | Polyamine biosynthetic process | IEA | biological_process |
| GO:0007283 | Spermatogenesis | NAS | biological_process |
| GO:0008792 | Arginine decarboxylase activity | IEA | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042978 | Ornithine decarboxylase activator activity | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0097055 | Agmatine biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2943286159 | 0.5228793739 | 0.9941997951 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0328004631 |
| GSE13712_SHEAR | Down | -0.1953259707 |
| GSE13712_STATIC | Up | 0.1619770723 |
| GSE19018 | Up | 0.1241135736 |
| GSE19899_A1 | Down | -0.1068631846 |
| GSE19899_A2 | Up | 0.3140891529 |
| PubMed_21979375_A1 | Down | -0.5556811414 |
| PubMed_21979375_A2 | Down | -0.0407466390 |
| GSE35957 | Down | -0.2051333220 |
| GSE36640 | Up | 0.4705527921 |
| GSE54402 | Down | -0.1335358122 |
| GSE9593 | Up | 0.3104878058 |
| GSE43922 | Up | 0.0550674509 |
| GSE24585 | Up | 0.4771692253 |
| GSE37065 | Up | 0.4563578749 |
| GSE28863_A1 | Down | -0.1032802889 |
| GSE28863_A2 | Down | -0.4666845259 |
| GSE28863_A3 | Down | -0.0501549919 |
| GSE28863_A4 | Down | -0.0016720705 |
| GSE48662 | Up | 0.1941118795 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Arginine | DB00125 | NUTR00014 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-151a-3p | MIMAT0000757 | MIRT043607 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30d-5p | MIMAT0000245 | MIRT047794 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25345926 | Patients with lung adenocarcinoma (ADC) exhibited significantly more positive staining of HOPX protein compared with lung squamous cell carcinoma (SCC) (p =0 |
| 25345926 | Again in ADC, patients with higher HOPX expression had a significantly longer disease-free survival (p =0 |
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