HCSGD entry for SLC46A1
1. General information
| Official gene symbol | SLC46A1 |
|---|---|
| Entrez ID | 113235 |
| Gene full name | solute carrier family 46 (folate transporter), member 1 |
| Other gene symbols | HCP1 PCFT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005215 | Transporter activity | IEA | molecular_function |
| GO:0005542 | Folic acid binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA ISS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0006879 | Cellular iron ion homeostasis | TAS | biological_process |
| GO:0008517 | Folic acid transporter activity | IDA | molecular_function |
| GO:0015232 | Heme transporter activity | IEA | molecular_function |
| GO:0015350 | Methotrexate transporter activity | IEA | molecular_function |
| GO:0015884 | Folic acid transport | IDA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016324 | Apical plasma membrane | IDA IEA | cellular_component |
| GO:0031526 | Brush border membrane | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046655 | Folic acid metabolic process | TAS | biological_process |
| GO:0055085 | Transmembrane transport | IEA TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5572663539 | 0.7109733939 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0712312349 |
| GSE13712_SHEAR | Up | 0.0096255485 |
| GSE13712_STATIC | Up | 0.2498952058 |
| GSE19018 | Up | 0.0265725170 |
| GSE19899_A1 | Down | -0.0277389445 |
| GSE19899_A2 | Down | -0.0724422977 |
| PubMed_21979375_A1 | Down | -0.3963353396 |
| PubMed_21979375_A2 | Down | -0.1422342354 |
| GSE35957 | Up | 0.0618046040 |
| GSE36640 | Up | 0.5339943809 |
| GSE54402 | Down | -0.2246578523 |
| GSE9593 | Up | 0.2535308368 |
| GSE43922 | Up | 0.0373005024 |
| GSE24585 | Up | 0.0706412590 |
| GSE37065 | Down | -0.0793162343 |
| GSE28863_A1 | Down | -0.1028467043 |
| GSE28863_A2 | Up | 0.4527292879 |
| GSE28863_A3 | Down | -0.2021395454 |
| GSE28863_A4 | Up | 0.0667977335 |
| GSE48662 | Up | 0.2594907838 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040975 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
