HCSGD entry for ECD
1. General information
| Official gene symbol | ECD |
|---|---|
| Entrez ID | 11319 |
| Gene full name | ecdysoneless homolog (Drosophila) |
| Other gene symbols | GCR2 HSGT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003713 | Transcription coactivator activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006110 | Regulation of glycolysis | TAS | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:2000045 | Regulation of G1/S transition of mitotic cell cycle | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1723677786 | 0.3574885415 | 0.8151346624 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2015148002 |
| GSE13712_SHEAR | Down | -0.1827455307 |
| GSE13712_STATIC | Up | 0.1479827639 |
| GSE19018 | Down | -0.5678722159 |
| GSE19899_A1 | Up | 0.4514671210 |
| GSE19899_A2 | Up | 0.2268914415 |
| PubMed_21979375_A1 | Up | 1.4042708584 |
| PubMed_21979375_A2 | Up | 0.3179471383 |
| GSE35957 | Down | -0.3158716104 |
| GSE36640 | Down | -0.3069489025 |
| GSE54402 | Up | 0.3725447674 |
| GSE9593 | Down | -0.1412832016 |
| GSE43922 | Up | 0.0162936065 |
| GSE24585 | Down | -0.1398090189 |
| GSE37065 | Up | 0.0873561513 |
| GSE28863_A1 | Down | -0.0105860911 |
| GSE28863_A2 | Up | 0.1961277305 |
| GSE28863_A3 | Down | -0.7993605563 |
| GSE28863_A4 | Up | 0.1926813316 |
| GSE48662 | Down | -0.4124186110 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025328 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044103 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23460854 | Using specular microscopy, the corneal endothelium was assessed for features of aging (low endothelial cell density [ECD], high variation in cell size, and low hexagonality index) |
| 23460854 | Among HIV-infected participants, low ECD was independently associated with current CD4 count <200 cells/microL (OR = 2 |
| 23460854 | In participants on ART with undetectable viral load, CDKN2A expression and 8-OHDG levels were higher in those with accelerated aging, as reflected by lower ECD |
| 19381346 | RESULTS: Our results indicated that the ECD values decreased with increasing age in both the SAM-R1 and SAM P8 series where the values in the older SAM p8 series decreased even lower than in the older SAM R1 series |
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