HCSGD entry for PARK7

1. General information

Official gene symbolPARK7
Entrez ID11315
Gene full nameparkinson protein 7
Other gene symbolsDJ-1 DJ1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003729MRNA bindingIDAmolecular_function
GO:0004601Peroxidase activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDA IMPcellular_component
GO:0005829CytosolIMPcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0006914AutophagyIEAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007005Mitochondrion organizationISSbiological_process
GO:0007338Single fertilizationIEAbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0008233Peptidase activityIDAmolecular_function
GO:0008344Adult locomotory behaviorIEAbiological_process
GO:0032091Negative regulation of protein bindingIDAbiological_process
GO:0042743Hydrogen peroxide metabolic processIEAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043523Regulation of neuron apoptotic processIDAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIDAbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0050681Androgen receptor bindingIPImolecular_function
GO:0050727Regulation of inflammatory responseISSbiological_process
GO:0050821Protein stabilizationIMPbiological_process
GO:0051583Dopamine uptake involved in synaptic transmissionIEAbiological_process
GO:0051899Membrane depolarizationIEAbiological_process
GO:0051920Peroxiredoxin activityIEAmolecular_function
GO:0055114Oxidation-reduction processISSbiological_process
GO:0060081Membrane hyperpolarizationIEAbiological_process
GO:0060548Negative regulation of cell deathIDAbiological_process
GO:0060765Regulation of androgen receptor signaling pathwayIDAbiological_process
GO:0070301Cellular response to hydrogen peroxideIDAbiological_process
GO:2000277Positive regulation of oxidative phosphorylation uncoupler activityIEAbiological_process
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85682083890.29546790400.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2182998682
GSE13712_SHEARDown-0.1359660509
GSE13712_STATICDown-0.0668119937
GSE19018Down-0.0422238800
GSE19899_A1Down-0.0814105401
GSE19899_A2Down-0.1323354589
PubMed_21979375_A1Down-0.5210685565
PubMed_21979375_A2Down-0.2705416037
GSE35957Down-0.0820475498
GSE36640Down-0.1611206139
GSE54402Up0.1214664797
GSE9593Down-0.0537139548
GSE43922Down-0.0204084478
GSE24585Down-0.0993828199
GSE37065Down-0.2109314205
GSE28863_A1Up0.1713803791
GSE28863_A2Up0.0066885991
GSE28863_A3Up0.5681429070
GSE28863_A4Up0.0340216167
GSE48662Down-0.3540808457

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Double Oxidized CysteineDB01769 EXPT01040

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029955MicroarrayFunctional MTI (Weak)19088304
hsa-miR-92b-3pMIMAT0003218MIRT040717CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046823CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049137CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.