HCSGD entry for KLF12
1. General information
| Official gene symbol | KLF12 |
|---|---|
| Entrez ID | 11278 |
| Gene full name | Kruppel-like factor 12 |
| Other gene symbols | AP-2rep AP2REP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA | molecular_function |
| GO:0001227 | RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | IEA | molecular_function |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9278426959 | 0.0402940124 | 0.9999902473 | 0.3790488563 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0366728742 |
| GSE13712_SHEAR | Down | -0.3112371277 |
| GSE13712_STATIC | Down | -0.0332930634 |
| GSE19018 | Up | 0.2547730249 |
| GSE19899_A1 | Down | -0.2716734949 |
| GSE19899_A2 | Down | -0.7272581672 |
| PubMed_21979375_A1 | Down | -1.1797517754 |
| PubMed_21979375_A2 | Down | -0.7758503969 |
| GSE35957 | Down | -0.1386849303 |
| GSE36640 | Down | -0.9760300500 |
| GSE54402 | Down | -0.2762012450 |
| GSE9593 | Down | -0.0906745973 |
| GSE43922 | Down | -0.6972160201 |
| GSE24585 | Down | -0.1597360611 |
| GSE37065 | Up | 0.2063309607 |
| GSE28863_A1 | Up | 0.3005379997 |
| GSE28863_A2 | Up | 0.1529273692 |
| GSE28863_A3 | Up | 0.0517702582 |
| GSE28863_A4 | Down | -0.0292843201 |
| GSE48662 | Up | 0.1300325070 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-101-3p | MIMAT0000099 | MIRT027368 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050396 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
