HCSGD entry for TREX1

1. General information

Official gene symbolTREX1
Entrez ID11277
Gene full namethree prime repair exonuclease 1
Other gene symbolsAGS1 CRV DRN3 HERNS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000738DNA catabolic process, exonucleolyticISS TASbiological_process
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003697Single-stranded DNA bindingIEA TASmolecular_function
GO:0005635Nuclear envelopeNAScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006259DNA metabolic processISSbiological_process
GO:0006260DNA replicationNASbiological_process
GO:0006281DNA repairTASbiological_process
GO:0006298Mismatch repairNASbiological_process
GO:0006308DNA catabolic processISS TASbiological_process
GO:0006310DNA recombinationNASbiological_process
GO:0008219Cell deathIEAbiological_process
GO:00082963'-5'-exodeoxyribonuclease activityIEA ISSmolecular_function
GO:00084083'-5' exonuclease activityIDA TASmolecular_function
GO:0008853Exodeoxyribonuclease III activityIEAmolecular_function
GO:0032405MutLalpha complex bindingIDAmolecular_function
GO:0032407MutSalpha complex bindingIDAmolecular_function
GO:0032479Regulation of type I interferon productionTASbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0032558Adenyl deoxyribonucleotide bindingIEAmolecular_function
GO:0035458Cellular response to interferon-betaIEAbiological_process
GO:0042803Protein homodimerization activityIEA NAS TASmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0046872Metal ion bindingNAS TASmolecular_function
GO:0090305Nucleic acid phosphodiester bond hydrolysisIDA ISS TASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99641835800.08896774060.99999024730.5659169164

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.5051139783

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.