HCSGD entry for USP18
1. General information
| Official gene symbol | USP18 |
|---|---|
| Entrez ID | 11274 |
| Gene full name | ubiquitin specific peptidase 18 |
| Other gene symbols | ISG43 UBP43 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004221 | Ubiquitin thiolesterase activity | IEA | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0060337 | Type I interferon signaling pathway | TAS | biological_process |
| GO:0060338 | Regulation of type I interferon-mediated signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0195027127 | 0.0434969112 | 0.3401739073 | 0.3927163867 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1441134931 |
| GSE13712_SHEAR | Up | 3.2810750315 |
| GSE13712_STATIC | Up | 1.8207780332 |
| GSE19018 | Down | -0.8620189068 |
| GSE19899_A1 | Down | -0.0448787971 |
| GSE19899_A2 | Down | -1.9965321981 |
| PubMed_21979375_A1 | Down | -1.3353448583 |
| PubMed_21979375_A2 | Down | -0.0731244726 |
| GSE35957 | Down | -2.7846188896 |
| GSE36640 | Up | 1.7248724802 |
| GSE54402 | Up | 0.4009507233 |
| GSE9593 | Up | 0.2189236633 |
| GSE43922 | Down | -0.9740435026 |
| GSE24585 | Up | 0.3689094826 |
| GSE37065 | Up | 1.1432116126 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.2584909077 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-221-3p | MIMAT0000278 | MIRT003365 | Reporter assay;Microarray | Non-Functional MTI | 20018759 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024799 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026176 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028905 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
