HCSGD entry for EGLN3
1. General information
| Official gene symbol | EGLN3 |
|---|---|
| Entrez ID | 112399 |
| Gene full name | egl nine homolog 3 (C. elegans) |
| Other gene symbols | HIFP4H3 HIFPH3 PHD3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IEP | biological_process |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006915 | Apoptotic process | IEP | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IEP | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IEA | biological_process |
| GO:0016706 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | IEA | molecular_function |
| GO:0018126 | Protein hydroxylation | IDA | biological_process |
| GO:0018401 | Peptidyl-proline hydroxylation to 4-hydroxy-L-proline | IDA | biological_process |
| GO:0031418 | L-ascorbic acid binding | IEA | molecular_function |
| GO:0031545 | Peptidyl-proline 4-dioxygenase activity | IDA | molecular_function |
| GO:0042127 | Regulation of cell proliferation | IEP | biological_process |
| GO:0043523 | Regulation of neuron apoptotic process | ISS | biological_process |
| GO:0061418 | Regulation of transcription from RNA polymerase II promoter in response to hypoxia | TAS | biological_process |
| GO:0071456 | Cellular response to hypoxia | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6435387865 | 0.6718678280 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1796823403 |
| GSE13712_SHEAR | Down | -0.0442032946 |
| GSE13712_STATIC | Up | 0.0377929266 |
| GSE19018 | Up | 0.3243695599 |
| GSE19899_A1 | Up | 0.1095088393 |
| GSE19899_A2 | Down | -0.0530940959 |
| PubMed_21979375_A1 | Up | 0.0366619775 |
| PubMed_21979375_A2 | Down | -0.0246620477 |
| GSE35957 | Up | 0.0299241798 |
| GSE36640 | Down | -0.1169777974 |
| GSE54402 | Down | -0.5593282792 |
| GSE9593 | Up | 0.0010435512 |
| GSE43922 | Up | 0.0783610046 |
| GSE24585 | Down | -0.1479948925 |
| GSE37065 | Up | 0.2502586776 |
| GSE28863_A1 | Down | -0.0611638290 |
| GSE28863_A2 | Down | -0.0011281223 |
| GSE28863_A3 | Up | 0.2899984862 |
| GSE28863_A4 | Up | 0.0777090958 |
| GSE48662 | Up | 0.0094246783 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Vitamin C | DB00126 | NUTR00001 | APRD00084 | EXPT00568 | DB09541 |
| FG-4592 | DB04847 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-20a-5p | MIMAT0000075 | MIRT006289 | Luciferase reporter assay//Western blot | Functional MTI | 22182733 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT003110 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19296470 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020155 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027522 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028026 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031128 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040873 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7i-5p | MIMAT0000415 | MIRT046547 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050427 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
