HCSGD entry for EGLN2
1. General information
| Official gene symbol | EGLN2 |
|---|---|
| Entrez ID | 112398 |
| Gene full name | egl nine homolog 2 (C. elegans) |
| Other gene symbols | EIT6 HIF-PH1 HIFPH1 HPH-1 HPH-3 PHD1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001558 | Regulation of cell growth | NAS | biological_process |
| GO:0001666 | Response to hypoxia | IDA IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0008198 | Ferrous iron binding | NAS | molecular_function |
| GO:0016706 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | IDA IEA | molecular_function |
| GO:0018401 | Peptidyl-proline hydroxylation to 4-hydroxy-L-proline | IDA | biological_process |
| GO:0019826 | Oxygen sensor activity | IDA | molecular_function |
| GO:0030520 | Intracellular estrogen receptor signaling pathway | NAS | biological_process |
| GO:0031418 | L-ascorbic acid binding | IEA | molecular_function |
| GO:0031543 | Peptidyl-proline dioxygenase activity | IEA | molecular_function |
| GO:0031545 | Peptidyl-proline 4-dioxygenase activity | IDA | molecular_function |
| GO:0043523 | Regulation of neuron apoptotic process | IMP | biological_process |
| GO:0045454 | Cell redox homeostasis | IDA | biological_process |
| GO:0045732 | Positive regulation of protein catabolic process | IDA | biological_process |
| GO:0061418 | Regulation of transcription from RNA polymerase II promoter in response to hypoxia | TAS | biological_process |
| GO:0071456 | Cellular response to hypoxia | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8641544812 | 0.5700412332 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1699031468 |
| GSE13712_SHEAR | Down | -0.1171523307 |
| GSE13712_STATIC | Up | 0.0805689429 |
| GSE19018 | Down | -0.1545028508 |
| GSE19899_A1 | Up | 0.0559195996 |
| GSE19899_A2 | Up | 0.1157428216 |
| PubMed_21979375_A1 | Up | 0.2832999198 |
| PubMed_21979375_A2 | Down | -0.2753554320 |
| GSE35957 | Down | -0.0288860906 |
| GSE36640 | Up | 0.0538106268 |
| GSE54402 | Up | 0.0025585193 |
| GSE9593 | Up | 0.0649686953 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.0476255711 |
| GSE28863_A2 | Down | -0.1823540942 |
| GSE28863_A3 | Down | -0.1128617390 |
| GSE28863_A4 | Up | 0.0571117926 |
| GSE48662 | Up | 0.2892655201 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Vitamin C | DB00126 | NUTR00001 | APRD00084 | EXPT00568 | DB09541 |
| FG-4592 | DB04847 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049430 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051206 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
