HCSGD entry for POLI
1. General information
| Official gene symbol | POLI |
|---|---|
| Entrez ID | 11201 |
| Gene full name | polymerase (DNA directed) iota |
| Other gene symbols | RAD30B RAD3OB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003684 | Damaged DNA binding | IEA | molecular_function |
| GO:0003887 | DNA-directed DNA polymerase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006261 | DNA-dependent DNA replication | TAS | biological_process |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9273237757 | 0.0302585198 | 0.9999902473 | 0.3285620875 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3451233312 |
| GSE13712_SHEAR | Up | 0.2963026878 |
| GSE13712_STATIC | Up | 0.3413141157 |
| GSE19018 | Up | 0.0484176423 |
| GSE19899_A1 | Down | -0.0212638561 |
| GSE19899_A2 | Down | -0.6505787552 |
| PubMed_21979375_A1 | Down | -1.1535137152 |
| PubMed_21979375_A2 | Down | -0.6280033306 |
| GSE35957 | Down | -0.5897230219 |
| GSE36640 | Up | 0.4180559150 |
| GSE54402 | Down | -0.3762581537 |
| GSE9593 | Down | -0.2052231958 |
| GSE43922 | Down | -0.3228005670 |
| GSE24585 | Up | 0.0771751024 |
| GSE37065 | Down | -0.0372994750 |
| GSE28863_A1 | Up | 0.0141634076 |
| GSE28863_A2 | Down | -0.0429204336 |
| GSE28863_A3 | Down | -0.3857075368 |
| GSE28863_A4 | Down | -0.0092788671 |
| GSE48662 | Down | -0.3617306592 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049053 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23893515 | We found that, whereas SUMO alone is widely distributed over the genome with strong association at active promoters, active sumoylation occurs most prominently at promoters of histone and protein biogenesis genes, as well as Pol I rRNAs and Pol III tRNAs |
| 23305233 | MK886 was found to inhibit the activity of all DNA polymerases tested with similar IC(50) values, the exception being a 6- to 8-fold increase in the potency of inhibition against human DNA polymerase iota (hpol iota), a highly error-prone enzyme that uses Hoogsteen base-pairing modes during catalysis |
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