HCSGD entry for ADCY6
1. General information
| Official gene symbol | ADCY6 |
|---|---|
| Entrez ID | 112 |
| Gene full name | adenylate cyclase 6 |
| Other gene symbols | AC6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004016 | Adenylate cyclase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005929 | Cilium | IEA | cellular_component |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0006171 | CAMP biosynthetic process | IDA | biological_process |
| GO:0006833 | Water transport | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007189 | Adenylate cyclase-activating G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007193 | Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007202 | Activation of phospholipase C activity | TAS | biological_process |
| GO:0007212 | Dopamine receptor signaling pathway | IDA | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0016020 | Membrane | ISS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019901 | Protein kinase binding | ISS | molecular_function |
| GO:0034199 | Activation of protein kinase A activity | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0071377 | Cellular response to glucagon stimulus | TAS | biological_process |
| GO:0071380 | Cellular response to prostaglandin E stimulus | IDA | biological_process |
| GO:0071870 | Cellular response to catecholamine stimulus | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1984709434 | 0.4715534820 | 0.8608924864 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1426397812 |
| GSE13712_SHEAR | Up | 0.1005972792 |
| GSE13712_STATIC | Up | 0.1151366644 |
| GSE19018 | Down | -0.0265478717 |
| GSE19899_A1 | Up | 0.1255629346 |
| GSE19899_A2 | Down | -0.5154338349 |
| PubMed_21979375_A1 | Down | -0.4479497209 |
| PubMed_21979375_A2 | Down | -0.3915768173 |
| GSE35957 | Down | -0.0030233902 |
| GSE36640 | Up | 1.5779154542 |
| GSE54402 | Down | -0.2900403752 |
| GSE9593 | Up | 0.4484781523 |
| GSE43922 | Up | 0.1121918490 |
| GSE24585 | Up | 0.1090310062 |
| GSE37065 | Down | -0.1148070555 |
| GSE28863_A1 | Up | 0.4583479986 |
| GSE28863_A2 | Up | 0.2982893559 |
| GSE28863_A3 | Down | -0.0719568247 |
| GSE28863_A4 | Down | -0.0701973742 |
| GSE48662 | Up | 0.3397819056 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-96-5p | MIMAT0000095 | MIRT001991 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-182-5p | MIMAT0000259 | MIRT001992 | Luciferase reporter assay//qRT-PCR | Functional MTI | 20656788 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT016723 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022147 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-96-5p | MIMAT0000095 | 3 | hsa-miR-96 | 17597072 | |||
| hsa-miR-96-5p | MIMAT0000095 | 6 | hsa-miR-96 | 17597072 | |||
| hsa-miR-96-5p | MIMAT0000095 | 1 | hsa-miR-96 | 17597072 | |||
| hsa-miR-96-5p | MIMAT0000095 | 5 | hsa-miR-96 | 17597072 | |||
| hsa-miR-96-5p | MIMAT0000095 | 4 | hsa-miR-96 | 17597072 | |||
| hsa-miR-96-5p | MIMAT0000095 | 2 | hsa-miR-96 | 17597072 | |||
| hsa-miR-182-5p | MIMAT0000259 | 1 | hsa-miR-182 | 17597072 | |||
| hsa-miR-182-5p | MIMAT0000259 | 4 | hsa-miR-182 | 17597072 | |||
| hsa-miR-182-5p | MIMAT0000259 | 3 | hsa-miR-182 | 17597072 | |||
| hsa-miR-182-5p | MIMAT0000259 | 5 | hsa-miR-182 | 17597072 | |||
| hsa-miR-182-5p | MIMAT0000259 | 6 | hsa-miR-182 | 17597072 | |||
| hsa-miR-182-5p | MIMAT0000259 | 2 | hsa-miR-182 | 17597072 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
