HCSGD entry for WIF1
1. General information
| Official gene symbol | WIF1 |
|---|---|
| Entrez ID | 11197 |
| Gene full name | WNT inhibitory factor 1 |
| Other gene symbols | WIF-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0045600 | Positive regulation of fat cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1639401580 | 0.8795518445 | 0.8011639250 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4107476045 |
| GSE13712_SHEAR | Down | -0.1279141765 |
| GSE13712_STATIC | Down | -0.2122681845 |
| GSE19018 | Up | 0.1938706110 |
| GSE19899_A1 | Down | -0.0006613713 |
| GSE19899_A2 | Down | -0.0724591403 |
| PubMed_21979375_A1 | Down | -0.0647425419 |
| PubMed_21979375_A2 | Up | 0.2070583569 |
| GSE35957 | Up | 1.0021884299 |
| GSE36640 | Down | -0.1634194536 |
| GSE54402 | Up | 0.8625772851 |
| GSE9593 | Up | 0.2514224370 |
| GSE43922 | Up | 0.0102996068 |
| GSE24585 | Up | 0.3284848359 |
| GSE37065 | Down | -0.0168108690 |
| GSE28863_A1 | Down | -0.0407203303 |
| GSE28863_A2 | Down | -0.0817921579 |
| GSE28863_A3 | Up | 0.0901642730 |
| GSE28863_A4 | Up | 0.0420242253 |
| GSE48662 | Up | 0.0227971538 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017148 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24853424 | Here we report for the first time that downregulation of the Wnt inhibitory factor 1 (WIF1) is a widespread event in salivary gland carcinoma ex-pleomorphic adenoma (CaExPA) |
| 24853424 | We also show that WIF1 downregulation occurs in the CaExPA precursor lesion pleomorphic adenoma (PA) and indicates a higher risk of progression from benign to malignant tumor |
| 24853424 | Our results demonstrate that diverse mechanisms including WIF1 promoter hypermethylation and loss of heterozygosity contribute to WIF1 downregulation in human salivary gland tumors |
| 24853424 | In accordance with a crucial role in suppressing salivary gland tumor progression, WIF1 re-expression in salivary gland tumor cells inhibited cell proliferation, induced more differentiated phenotype and promoted cellular senescence, possibly through upregulation of tumor-suppressor genes, such as p53 and p21 |
| 24853424 | Most importantly, WIF1 significantly diminished the number of salivary gland cancer stem cells and the anchorage-independent cell growth |
| 24853424 | Consistent with this observation, WIF1 caused a reduction in the expression of pluripotency and stemness markers (OCT4 and c-MYC), as well as adult stem cell self-renewal and multi-lineage differentiation markers, such as WNT3A, TCF4, c-KIT and MYB |
| 24853424 | Furthermore, WIF1 significantly increased the expression of microRNAs pri-let-7a and pri-miR-200c, negative regulators of stemness and cancer progression |
| 24853424 | In addition, we show that WIF1 functions as a positive regulator of miR-200c, leading to downregulation of BMI1, ZEB1 and ZEB2, with a consequent increase in downstream targets such as E-cadherin |
| 24853424 | Our study emphasizes the prognostic and therapeutic potential of WIF1 in human salivary gland CaExPA |
| 24853424 | Moreover, our findings demonstrate a novel mechanism by which WIF1 regulates cancer stemness and senescence, which might have major implications in the field of cancer biology |
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