HCSGD entry for MAP4K5
1. General information
| Official gene symbol | MAP4K5 |
|---|---|
| Entrez ID | 11183 |
| Gene full name | mitogen-activated protein kinase kinase kinase kinase 5 |
| Other gene symbols | GCKR KHS KHS1 MAPKKKK5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IBA | biological_process |
| GO:0000185 | Activation of MAPKKK activity | IBA | biological_process |
| GO:0004672 | Protein kinase activity | IEA TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005083 | Small GTPase regulator activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005737 | Cytoplasm | IBA IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007165 | Signal transduction | IBA | biological_process |
| GO:0007257 | Activation of JUN kinase activity | TAS | biological_process |
| GO:0008349 | MAP kinase kinase kinase kinase activity | IBA | molecular_function |
| GO:0023014 | Signal transduction by phosphorylation | IBA | biological_process |
| GO:0035556 | Intracellular signal transduction | IBA IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6999502792 | 0.0531296455 | 0.9999902473 | 0.4344052795 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2150367395 |
| GSE13712_SHEAR | Up | 0.3614249749 |
| GSE13712_STATIC | Up | 0.0922579699 |
| GSE19018 | Up | 0.0416908207 |
| GSE19899_A1 | Down | -0.8004753958 |
| GSE19899_A2 | Down | -0.9755828919 |
| PubMed_21979375_A1 | Down | -0.8874004511 |
| PubMed_21979375_A2 | Down | -0.9655791243 |
| GSE35957 | Up | 0.1520676440 |
| GSE36640 | Down | -0.1338275375 |
| GSE54402 | Down | -0.2553940829 |
| GSE9593 | Up | 0.4842098281 |
| GSE43922 | Down | -0.6585216866 |
| GSE24585 | Up | 0.0083068899 |
| GSE37065 | Down | -0.0807574924 |
| GSE28863_A1 | Up | 0.1292579955 |
| GSE28863_A2 | Up | 0.2349779514 |
| GSE28863_A3 | Down | -0.1330276828 |
| GSE28863_A4 | Up | 0.2492201729 |
| GSE48662 | Down | -0.0222520567 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
