HCSGD entry for FAF1
1. General information
| Official gene symbol | FAF1 |
|---|---|
| Entrez ID | 11124 |
| Gene full name | Fas (TNFRSF6) associated factor 1 |
| Other gene symbols | HFAF1s UBXD12 UBXN3A hFAF1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005635 | Nuclear envelope | IEA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007253 | Cytoplasmic sequestering of NF-kappaB | IMP | biological_process |
| GO:0008219 | Cell death | IMP | biological_process |
| GO:0019887 | Protein kinase regulator activity | NAS | molecular_function |
| GO:0019901 | Protein kinase binding | IDA | molecular_function |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0030155 | Regulation of cell adhesion | IEA | biological_process |
| GO:0031072 | Heat shock protein binding | IDA | molecular_function |
| GO:0031265 | CD95 death-inducing signaling complex | NAS | cellular_component |
| GO:0031334 | Positive regulation of protein complex assembly | IMP | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IDA | molecular_function |
| GO:0034098 | Cdc48p-Npl4p-Ufd1p AAA ATPase complex | IDA | cellular_component |
| GO:0042176 | Regulation of protein catabolic process | IMP | biological_process |
| GO:0042325 | Regulation of phosphorylation | NAS | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | NAS | biological_process |
| GO:0043130 | Ubiquitin binding | IDA | molecular_function |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | NAS | biological_process |
| GO:0045859 | Regulation of protein kinase activity | NAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0050790 | Regulation of catalytic activity | NAS | biological_process |
| GO:0051059 | NF-kappaB binding | IPI | molecular_function |
| GO:1902043 | Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9543973861 | 0.0421155085 | 0.9999902473 | 0.3858413853 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1049867684 |
| GSE13712_SHEAR | Down | -0.0235965292 |
| GSE13712_STATIC | Down | -0.1795853779 |
| GSE19018 | Up | 0.1233170651 |
| GSE19899_A1 | Down | -0.2261342769 |
| GSE19899_A2 | Down | -0.6929143343 |
| PubMed_21979375_A1 | Down | -0.6926767779 |
| PubMed_21979375_A2 | Down | -0.6027560331 |
| GSE35957 | Down | -0.1596435184 |
| GSE36640 | Down | -0.6210819593 |
| GSE54402 | Down | -0.3957320581 |
| GSE9593 | Down | -0.0198995397 |
| GSE43922 | Down | -0.3666831367 |
| GSE24585 | Down | -0.0976797727 |
| GSE37065 | Down | -0.1306566061 |
| GSE28863_A1 | Up | 0.5427230934 |
| GSE28863_A2 | Up | 0.5699974194 |
| GSE28863_A3 | Down | -0.1687941307 |
| GSE28863_A4 | Down | -0.0667666022 |
| GSE48662 | Down | -0.2982135784 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | MIRT006507 | Luciferase reporter assay//Western blot | Functional MTI | 20195546 |
| hsa-miR-146a-5p | MIMAT0000449 | MIRT003319 | GFP reporter assay//qRT-PCR | Functional MTI | 20459811 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029548 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041238 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041754 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049059 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
